Application of Cerium (IV) as an Oxidimetric Agent for the Determination of Ethionamide in Pharmaceutical Formulations

Table 4

Results of analysis of tablets by the proposed methods and statistical comparison of the results with the reference method.

Tablet brand name	Nominal amount	Found (% of nominal amount ± SD)
		Reference method	Proposed methods
			Titrimetry	Spectrophotometry
Ethide	250	100.2 ± 1.23	99.88 ± 1.02	100.44 ± 1.86; = 0.24
Ethiokox	250	96.22 ± 1.45	98.4 ± 1.71; = 2.17	98.06 ± 2.46; = 1.44
Myobid	250	97.34 ± 1.54	98.96 ± 1.85; = 1.51	95.84 ± 1.78; = 1.43

Mean value of five determinations.
(Tabulated -value at the 95% confidence level and for four degrees of freedom is 2.78).
(Tabulated -value at the 95% confidence level and for four degrees of freedom is 6.39).