Research Article

Application of Cerium (IV) as an Oxidimetric Agent for the Determination of Ethionamide in Pharmaceutical Formulations

Table 6

Comparison of the proposed and the existing spectrophotometric and titrimetric methods for the determination of ETM.
(a) Spectrophotometry

SL numberReagent/sMethodologyLinear range (µg/mL)RemarkRef.

1DCNQOrange coloured product in ethanol measured at 440 nm[9]
2DCNQRed coloured product formed in the presence of ammonia in alcoholic medium measured at 540 nm6–4220 min contact time[10]
3Iron (III)Purple-violet colour complex in acid medium measured at 510 nm0–36Less sensitive and the molar absorptivity is equal to 2.48 × 103 L/(mol⋅cm)[11]
4Iron (III) PPDThionine compound measured at 600 nmMultiple step reaction involved[12]
5Sodium nitroprussideOrange coloured product in basic medium measured at 510 nm[13]
6Sodium nitroprussideOrange-red complex measured at 490 nm5–32[14]
7PAR-V+5Ternary complex (1 : 1 : 1) extracted into chloroform and measured at 560 nm0.2–2030 min contact time, extraction step is required[15]
8Osmic acidLight yellow coloured product formed at pH4 measured at 375 nm0.25–4060 min contact time, pH adjustment is required[16]
9NBS-CBUnbleached dye colour measured in acid medium at 540 nm0.2–5.0Critical acid conc.; less stable reagent used[17]
10KMnO4Blue coloured manganate in alkaline medium measured at 610 nm (direct method)1–10Critical NaOH conc.
Reaction rate precariously dependent on experimental variables
[18]
Absorbance at a fixed time of 20 min measured (kinetic method)1–10
11Sodium azide-iodineDecrease in absorbance at the 5th min measured at 348 nm (kinetic method)10–100Reaction rate precariously dependent on experimental conditions[19]
12Ce(IV)/ODSOrange-red coloured species measured at 470 nm0.5–5.0Nondrastic experimental conditions, no critical pH adjust, no heating or extraction step. Shorter contact time (15 min), no use of organic solventPresent work

(b) Titrimetry

SL numberReagent/sEnd point detectionLinear rangeRemarkRef.

1NBSVisuallyLess stable oxidant used[20]
2I2-NaOHPotentiometrically25–500 μ molCritically dependent on alkaline concentration[21]
3AgNO3PotentiometricallyPreparation of AgS-sensor is tedious & cumbersome, expensive titrant used[22]
4Ce(IV)/FASUnreacted Ce titrated versus FAS1–8 mgStable titrant used, facile working conditions employedPresent work

DCNQ: Dichloronaphthoquinone; PAR: 4-(2-pyridylazo) resorcinol; PPD: p-phenylenediamine; NBS: N-bromosuccinimide; CB: Celestine blue; ODS: ortho-dianisidine; FAS: ferrous ammonium sulphate.