In Vitro and In Vivo Correlation of Colon-Targeted Compression-Coated Tablets

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Composition of coating material</td><td class="align_center">Weight (mg)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">CMXG </td><td class="align_center">18.75</td></tr><tr><td class="align_left">SAL </td><td class="align_center">43.75</td></tr><tr><td class="align_left">CaCl<sub>2 </sub></td><td class="align_center">12.50</td></tr><tr><td class="align_left">Total </td><td class="align_center">75</td></tr><tr><td class="align_center" colspan="2"><hr/></td></tr><tr><td class="align_center" colspan="2">Physical characteristics of coated tablet</td></tr><tr><td class="align_left">Thickness (mm)</td><td class="align_center">3.62 ± 0.04</td></tr><tr><td class="align_left">Friability (%)</td><td class="align_center">0.78</td></tr><tr><td class="align_left">Weight variation (%)</td><td class="align_center">−3.26 to 2.00</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Composition and physical characteristics of compression-coated tablet.

Journal of Pharmaceutics

tab2

Table 2

Table 2: In Vitro and In Vivo Correlation of Colon-Targeted Compression-Coated Tablets 