Quantification of Warfarin in Dried Rat Plasma Spots by High-Performance Liquid Chromatography with Tandem Mass Spectrometry

Table 1

Intra- and interday accuracy (% bias) and precision (% RSD) for LLOQ and quality control samples of warfarin.

Level	Nominal conc. (ng/mL)	Intraday		Interday
		% bias	% RSD	% bias	% RSD
LLOQ	10	1.9	12.5	10.0	18.0
LQC	50	11.9	7.9	6.5	11.8
MQC	800	−1.6	7.2	0.8	9.7
HQC	4000	12.8	11.6	6.7	10.8

Three replicates for LLOQ; 12 replicates for LQC, MQC, and HQC each.
Nine replicates for LLOQ; 24 replicates for LQC, MQC, and HQC each.