Research Article
Cellulose Acetate 398-10 Asymmetric Membrane Capsules for Osmotically Regulated Delivery of Acyclovir
Table 4
Percent drug content, weight uniformity, and cumulative drug release data of the asymmetric membrane capsules of acyclovir.
| Formulation code | Weight (mg) ± S.D. | Drug content (%) ± S.D. | (%) ± S.D. |
| F1 | 697.60 ± 1.18 | 97.74 ± 0.55 | 70.07 ± 1.93 | F2 | 697.80 ± 1.05 | 98.21 ± 0.60 | 70.04 ± 1.36 | F3 | 697.95 ± 0.99 | 98.36 ± 0.54 | 91.16 ± 0.30 | F4 | 698.40 ± 0.75 | 92.61 ± 1.44 | 84.11 ± 0.95 | F5 | 769.10 ± 0.91 | 94.63 ± 1.08 | 80.59 ± 1.48 | F6 | 768.75 ± 1.06 | 93.23 ± 1.33 | 74.63 ± 0.46 | F7 | 769.35 ± 0.74 | 99.45 ± 0.37 | 97.88 ± 0.77 | F8 | 769.00 ± 1.02 | 96.65 ± 1.51 | 86.86 ± 1.25 | F9 | 732.95 ± 1.09 | 97.12 ± 1.08 | 95.20 ± 0.75 |
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Average of 20 determinations; average of five determinations. Extra design check point.
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