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Journal of Pharmaceutics
Volume 2017 (2017), Article ID 3690473, 5 pages
Research Article

Formulation and Evaluation of New Glimepiride Sublingual Tablets

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sana’a University, Sana’a, Yemen
2Department of Pharmacy, Faculty of Medicine and Health Sciences, Yemeni Jordanian University, Sana’a, Yemen
3Department of Pharmacy, Faculty of Medicine and Health Sciences, Thamar University, Dhamar, Yemen
4Department of Biomedical Science, Sana’a University, Sana’a, Yemen

Correspondence should be addressed to Wafa Al-Madhagi

Received 19 June 2016; Accepted 3 October 2016; Published 5 February 2017

Academic Editor: Francisco Javier Flores-Murrieta

Copyright © 2017 Wafa Al-Madhagi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glimepiride formula for sublingual administration and rapid drug absorption that can be used in an emergency. The new sublingual formulation was prepared after five trials to prepare the suitable formulation. Two accepted formulations of the new sublingual product were prepared, but one of them with disintegration time of 1.45 min and searching for preferred formulation, the binder, is changed with Flulac and starch slurry to prepare formula with disintegration time of 21 seconds that supports the aim of research to be used in an emergency. The five formulations were done, after adjusting to the binder as Flulac and aerosil with disintegration time of 21 seconds and accepted hardness as well as the weight variation. The assay of a new product (subglimepiride) is 103% which is a promising result, confirming that the formula succeeded. The new product (subglimepiride) is accepted in most quality control tests and it is ready for marketing.