Combined Effect of Synthetic and Natural Polymers in Preparation of Cetirizine Hydrochloride Oral Disintegrating Tablets: Optimization by Central Composite Design

Table 4

Response variables () obtained from trial formulations of CTZ ODTs.

Trial run	Croscarmellose sodium (mg) (X1)	H. rosa-sinensis mucilage (mg) (X2)	Disintegration time (sec) (Y1)	Friability (%) (Y2)	Cumulative drug released (%) (Y3)
1	5	10	22
2	10	10	17
3	15	10	16
4	5	20	15
5	10	20	12
6	15	20	14
7	5	30	16
8	10	30	18
9	15	30	20
10	10	20	13
11	10	20	12
12	10	20	12
13	10	20	12