Research Article
Association of PLGA Microspheres to Carrier Pellets by Fluid Bed Coating: A Novel Approach towards Improving the Flowability of Microparticles
Table 3
Densities and flow-indicative parameters of the products.
| | Parameters | C. glaziovii extract | Microspheres | Carrier pellets | Coated pellets |
| | Bulk density (g/cm3) | 0.31 ± 0.01 | 0.11 ± 0.01 | 0.69 ± 0.02 | 0.74 ± 0.03 | | Tapped density (g/cm3) | 0.40 ± 0.02 | 0.21 ± 0.01 | 0.74 ± 0.01 | 0.78 ± 0.02 | | True density (g/cm3) | 1.564 ± 0.002 | 1.461 ± 0.001 | 1.499 ± 0.001 | 1.571 ± 0.005 | | Hausner ratio | 1.27 ± 0.02 | 1.81 ± 0.01 | 1.05 ± 0.01 | 1.03 ± 0.01 | | Carr’s index (%) | 21.0 ± 1.4 | 44.7 ± 0.2 | 5.3 ± 1.0 | 11.8 ± 0.8 | | Angle of repose (°) | 37.8 ± 1.4 | 48.4 ± 1.3 | 20.9 ± 0.6 | 14.5 ± 0.3 |
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