Genotoxicity Revaluation of Three Commercial Nitroheterocyclic Drugs: Nifurtimox, Benznidazole, and Metronidazole
Table 1
Specific mutagenic activity (revertant increase/dose unit calculated by linear regression analysis on the curve section with response linearity) of NFX, BNZ, and MTZ on different Salmonella strains without or with (+) S9 mix; in brackets: 2 value (A). Positive controls are reported for each strain (HYC: hycantone; 2-AF: 2-aminofluorene; FYFA: furylfuramide; 2NF: 2-nitrofluorene); mean (±SD) of three plates (B). *P < .05 Dunnett’s C.
