Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="8"><hr/></td></tr><tr class="thead"><td align="left"> Crude extract</td><td align="center">Solvent</td><td align="center">IC50 D10 (μg/mL)</td><td align="center">IC50 DD2 (μg/mL)</td><td align="center">IC50 CHO (μg/mL)</td><td align="center"> (SI) D10</td><td align="center"> (SI) DD2</td><td align="center"> RI</td></tr><tr><td class="thead-hr" colspan="8"><hr/></td></tr><tr><td align="left">Carica papaya</td><td align="center">EA</td><td align="center">2.96 ± 0.14</td><td align="center">3.98 ± 0.42</td><td align="center">737.8 ± 0.28</td><td align="center">249.25</td><td align="center">185.37</td><td align="center">1.34</td></tr><tr class="table-tr"><td colspan="8"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>SI = IC50 cytotoxicity/IC50 antiplasmodial activity. RI = IC50 of resistant strain (DD2)/IC50 of sensitive strain (D10). </td></tr></table>

In vitro antiplasmodial activity of Carica papaya on Plasmodium falciparum cultures and toxicity towards the CHO cell line.

Journal of Parasitology Research

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Table 2

Table 2: Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves