The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi

Table 1

Antioxidant defenses and drug susceptibility of T. cruzi strains.

Strain	DTU*	Redox state	Drug susceptibility	Reference
Y	II	Low concentrations of antioxidant enzymes; lower activity of G6PDH	Resistant	[42, 44]
Tulahuen	VI	High concentrations of antioxidant enzymes; higher activity of G6PDH; lower Thiol contents	Susceptible	[42, 44, 65]
Colombiana	I	High concentrations of antioxidant enzymes; no alteration of TcCPX and TcMPX and FeSOD isoforms	Resistant (natural)	[42, 69–71]
Cl Brener	VI	No alteration of TcCPX and TcMPX and FeSOD isoforms	Susceptible (in vitro)	[69–71]

*Discrete typing units (DTUs), according to Zingales et al., 2009 [43].