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Journal of Parasitology Research
Volume 2012, Article ID 296856, 11 pages
Clinical Study

The Effect of Antihelminthic Treatment on Subjects with Asthma from an Endemic Area of Schistosomiasis: A Randomized, Double-Blinded, and Placebo-Controlled Trial

1Serviço de Imunologia, Universidade Federal da Bahia (UFBA), 40110-160 Salvador, BA, Brazil
2Departamento de Ciências da Vida, Universidade do Estado da Bahia UNEB, 41.150-000 Salvador, BA, Brazil
3Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais (INCT-DT/CNPq-MCT), Brazil
4ProAR, Núcleo de Excelência em Asma, Universidade Federal da Bahia 40110-160 Salvador, BA, Brazil
5Faculdade de Farmácia, UFBA 40110-160 Salvador, BA, Brazil
6Escola Bahiana de Medicina e Saúde Pública, EBMSP, Salvador, Bahia, Brazil

Received 14 April 2012; Revised 15 June 2012; Accepted 21 June 2012

Academic Editor: Elena Pinelli

Copyright © 2012 Maria Cecilia F. Almeida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This is a prospective, double-blinded, and placebo-controlled trial evaluating the influence of antihelminthic treatments on asthma severity in individuals living in an endemic area of schistosomiasis. Patients from group 1 received placebo of Albendazole or of Praziquantel and from group 2 received Albendazole and Praziquantel. Asthma severity was assessed by clinical scores and by pulmonary function test. There was no significant difference in the asthma scores from D0 to D1–D7 after Albendazole or Praziquantel and from D0 to D30–90 after Albendazole or Praziquantel in both, group 1 and 2. It was observed, however, a clinical worsening of the overall studied population after 6 months and 12 months of antihelminthic treatments. Additionally, we observed increased frequency of forced expiratory volume in 1 second (FEV1) < 8 0 % on 12 and 18 months after treatment. The worsening of asthma severity after repeated antihelminthic treatments is consistent with the hypothesis of the protective role conferred by helminths in atopic diseases.