The Effect of Antihelminthic Treatment on Subjects with Asthma from an Endemic Area of Schistosomiasis: A Randomized, Double-Blinded, and Placebo-Controlled Trial
Table 2
Levels of cytokines in supernatants of PBMC cultures in the studied subjects.
Cytokine
Antigen
D0
D7
D90
G1/placebo
G2/PZQ
G1/placebo
G2/PZQ
G1/placebo
G2/PZQ
IFN-γ
Without stimulus
32.7 (31.2–276.0)
31.6 (31.2–91.0)
31.2 (31.2–46.7)
39.7 (31.2–583.6)
31.2 (31.2–130.7)
32.7 (31.2–2563.0)
SWAP
149.5 (42.0–10337.0)
88.0 (31.2–2092.0)
56.0 (43.8–1415.0)
137.8 (37.4–15543.0)
70.0 (15.6–3329.0)
130.7 (31.2–2563.0)
Der p1
338.5 (102.4–7475.0)
710.0 (149.0–2568.0)
116.7 (42.0–420.2)
333.9 (32.7–9669.0)
201.0 (31.2–4818.0)
149.4 (15.6–1275.0)
IL-5
Without stimulus
15.6 (15.6–112.0)
15.6 (15.6-15.6)
15.6 (15.6-15.6)
15.6 (15.6–40.7)
15.6 (15.6–25.0)
15.6 (15.6–635.0)
SWAP
468.5 (15.6–5156.0)
310.2 (15.6–5904.0)
542.0 (15.6–4444.0)
1863.0 (15.6–4606.0)
1670.0 (21.5–4444.0)
2850 (136.0–4444.0)
Der p1
150.0 (15.6–630.0)a
463.0 (207.0–4606.0)a
28.8 (15.6–407.4)
60.0 (15.6–4606.0)
28.7 (15.6–1720.0)
352.0 (15.6–3509.0)
IL-10
Without stimulus
27.5 (15.6–475.0)
28.0 (15.6–102.0)
57.0 (16.8–589.0)
23.1 (15.6–1144.0)
36.0 (15.6–446.9)
15.6 (15.6–127.0)
SWAP
264.5 (26.0–1688.0)
642.0 (125.0–1132.0)b
288.0 (29.4–641.0)
667.3 (15.6–2447.0)
240.0 (21.1–638.4)
175.6 (60.3–1062.0)b
Der p1
451.0 (56.0–1060.0)
349.0 (177.0–1539.0)
924.0 (297.1–2063.0)
288.0 (15.6–2086.0)
390.0 (54.3–1744.0)
204.0 (60.0–638.0)
Data showed as median (minimum and maximum values) pg/ml;
aPlacebo D0 versus PZQ D0 (Mann-Whitney -test);
bPZQ D0 versus PZQ D90 (Wilcoxon matched-pairs signs ranks test).
