Journal of Parasitology Research / 2012 / Article / Tab 2

Research Article

Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection

Table 2

Levels of cytokines produced by peripheral blood mononuclear cells (PBMC) of studied individuals.

Cytocines (pg/mL) Without fibrosis Incipient fibrosis Moderate to severe
median (min–max)( ) ( )Fibrosis ( )

IL-5
 Without antigen31.2 (31.2–112.2)31.2 (31.2–75.5)31.2 (31.2–127.8)ns
 SWAP374.4 (31.2–5153.0)524 (31.2–5905.0)1988.0 (31.2–5135.0)ns
 SEA36.8 (31.2–3820.0)188.4 (31.2–4232.0)310.9 (31.2–4256.0)0.0418 a
IL-13
 Without antigen112.4 (93.8–186.8)93.8 (93.8–166.0)93.8 (93.8–93.8)ns
 SWAP246.6 (93.8–1518.0)190.3 (93.8 –1290.0)213.7 (93.8–2091.0)ns
 SEA171.2 (93.8–1497.0)93.8 (93.8–1442.0)93.8 (93.8–1857.0)ns
IL-17
 Without antigen15.6 (15.6–132.9)15.6 (15.6–84.1)15.6 (15.6–90.7)ns
 SWAP21.4 (15.6–790.5)57.1 (15.6–974.8)21.4 (15.6–345.2)ns
 SEA18.9 (15.6–291.1)15.6 (15.6–615.3)27.2 (15.6–557.5)ns
IFN-γ
 Without antigen31.2 (31.2–276.2)31.9 (31.2–1788.0)31.2 (31.2–777.7)ns
 SWAP73.1 (31.2–3038.0)1205.0 (31.2–5507.0)215.8 (31.2–5249.0)ns
 SEA83.1 (31.2–288.0)203.8 (31.2–2905.0)130.1 (31.2–2714.0)ns
TNF-α
 Without antigen61.9 (31.2–633.3)346.6 (31.2–2421.0)488.7 (31.23229.0)0.0182 a
 SWAP756.1 (80.6–3366.0)1446.0 (236.4–3057.0)1002.0 (35.7–2351.0)0.0319 b
 SEA389.8 (102.7–2521.0)827.3 (31.2–3551.0)927.3 (89.1–2517.0)ns
IL-10
 Without antigen15.6 (15.6–705.5)48.6 (15.6–1486.0)17.5 (15.6–1262.0)ns
 SWAP393.8 (22.1–1976.0)399.6 (15.6–1779.0)318.1 (15.6–1213.0)ns
 SEA585.7 (175.7–2075.0)1342.0 (15.6–2472.0)745.8 (35.5–1543.0)ns

*Kruskal-Wallis; awithout fibrosis versus moderate to severe fibrosis; bwithout fibrosis versus incipient fibrosis; ns: not significant ( ).
SWAP: soluble worm antigen preparation of adult Schistosoma mansoni; SEA: Schistosoma mansoni egg antigen.