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Journal of Parasitology Research
Volume 2012 (2012), Article ID 413052, 12 pages
http://dx.doi.org/10.1155/2012/413052
Review Article

Macrophage Migration Inhibitory Factor in Protozoan Infections

Laboratório de Inflamação e Imunidade, Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil

Received 2 September 2011; Revised 1 November 2011; Accepted 7 November 2011

Academic Editor: Marcela F. Lopes

Copyright © 2012 Marcelo T. Bozza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Macrophage migration inhibitory factor (MIF) is a cytokine that plays a central role in immune and inflammatory responses. In the present paper, we discussed the participation of MIF in the immune response to protozoan parasite infections. As a general trend, MIF participates in the control of parasite burden at the expense of promoting tissue damage due to increased inflammation.