Table of Contents Author Guidelines Submit a Manuscript
Journal of Parasitology Research
Volume 2012, Article ID 507874, 12 pages
http://dx.doi.org/10.1155/2012/507874
Review Article

The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development

1Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo (UNIFESP), 04044-010 São Paulo, SP, Brazil
2Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), 21941-902 Rio de Janeiro, RJ, Brazil
3Instituto de Microbiologia Paulo de Góes, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Avenida Carlos Chagas Filho, 373 Bloco D, sala 35, Cidade Universitária, 21941-902 Rio de Janeiro, RJ, Brazil

Received 1 September 2011; Accepted 31 October 2011

Academic Editor: Marcela F. Lopes

Copyright © 2012 Mauricio M. Rodrigues et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [37 citations]

The following is the list of published articles that have cited the current article.

  • Astrid Schmieder, Kai Schledzewski, Julia Michel, Kathrin Schönhaar, Yannick Morias, Tom Bosschaerts, Jan Van den Bossche, Pierre Dorny, Andrea Sauer, Carsten Sticht, Cyrill Géraud, Zoe Waibler, Alain Beschin, and Sergij Goerdt, “The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection,” European Journal of Immunology, vol. 42, no. 11, pp. 2971–2982, 2012. View at Publisher · View at Google Scholar
  • Antonio Gigliotti Rothfuchs, Ester Roffe, Amanda Gibson, Allen W. Cheever, R. Alan B. Ezekowitz, Kazue Takahashi, Mario Steindel, Alan Sher, and Andre Bafica, “Mannose-Binding Lectin Regulates Host Resistance and Pathology during Exper imental Infection with Trypanosoma cruzi,” Plos One, vol. 7, no. 11, 2012. View at Publisher · View at Google Scholar
  • Humberto D. Gravina, Lis Antonelli, Ricardo T. Gazzinelli, and Catherine Ropert, “Differential Use of TLR2 and TLR9 in the Regulation of Immune Responses during the Infection with Trypanosoma cruzi,” Plos One, vol. 8, no. 5, 2013. View at Publisher · View at Google Scholar
  • Virginia M. Goncalves, Kely C. Matteucci, Carina L. Buzzo, Bruna H. Miollo, Danny Ferrante, Ana C. Torrecilhas, Mauricio M. Rodrigues, Jose M. Alvarez, and Karina R. Bortoluci, “NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production,” Plos Neglected Tropical Diseases, vol. 7, no. 10, 2013. View at Publisher · View at Google Scholar
  • Aline Guilmot, Julie Bosse, Yves Carlier, and Carine Truyens, “Monocytes Play an IL-12-Dependent Crucial Role in Driving Cord Blood NK Cells to Produce IFN-g in Response to Trypanosoma cruzi,” Plos Neglected Tropical Diseases, vol. 7, no. 6, 2013. View at Publisher · View at Google Scholar
  • Alicia Vázquez-Mendoza, Julio César Carrero, and Miriam Rodriguez-Sosa, “Parasitic Infections: A Role for C-Type Lectins Receptors,” BioMed Research International, vol. 2013, pp. 1–11, 2013. View at Publisher · View at Google Scholar
  • Ana Fernández-Villegas, M. Carmen Thomas, Bartolomé Carrilero, Cinta Téllez, Concepción Marañón, Laura Murcia, Sara Moralo, Carlos Alonso, Manuel Segovia, and Manuel Carlos López, “The innate immune response status correlates with a divergent clinical course in congenital Chagas disease of twins born in a non-endemic country,” Acta Tropica, 2014. View at Publisher · View at Google Scholar
  • Jia Shen, Lian Xu, Zhen Liu, Na Li, Lifu Wang, Zhiyue Lv, Mingchiu Fung, Zhongdao Wu, and Xi Sun, “Gene expression profile of LPS-stimulated dendritic cells induced by a recombinant Sj16 (rSj16) derived from Schistosoma japonicum,” Parasitology Research, 2014. View at Publisher · View at Google Scholar
  • Fernando J Sánchez-Valdéz, Cecilia Pérez Brandán, Arturo Ferreira, and Miguel Ángel Basombrío, “Gene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease,” Expert Review of Vaccines, pp. 1–17, 2014. View at Publisher · View at Google Scholar
  • Fernando dos Santos Virgilio, Camila Pontes, Mariana Ribeiro Dominguez, Jonatan Ersching, Mauricio Martins Rodrigues, and José Ronnie Vasconcelos, “ CD8 + T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development? ,” Mediators of Inflammation, vol. 2014, pp. 1–12, 2014. View at Publisher · View at Google Scholar
  • Adriano Fernando Araújo, Gabriel de Oliveira, Juliana Fraga Vasconcelos, Jonatan Ersching, Mariana Ribeiro Dominguez, José Ronnie Vasconcelos, Alexandre Vieira Machado, Ricardo Tostes Gazzinelli, Oscar Bruna-Romero, Milena Botelho Soares, and Mauricio Martins Rodrigues, “ Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi ,” Mediators of Inflammation, vol. 2014, pp. 1–13, 2014. View at Publisher · View at Google Scholar
  • Francisca Vorraro, Wafa H. K. Cabrera, Orlando G. Ribeiro, José Ricardo Jensen, Marcelo De Franco, Olga M. Ibañez, and Nancy Starobinas, “ Trypanosoma cruzi Infection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response ,” Mediators of Inflammation, vol. 2014, pp. 1–15, 2014. View at Publisher · View at Google Scholar
  • Akhilesh Singh, Ravindra Kumar Garg, Amita Jain, Hardeep Singh Malhotra, Shantanu Prakash, Rajesh Verma, and Praveen Kumar Sharma, “Toll like receptor-4 gene polymorphisms in patients with solitary cysticercus granuloma,” Journal of the Neurological Sciences, 2015. View at Publisher · View at Google Scholar
  • Shivali Gupta, and Nisha J. Garg, “A Two-Component DNA-Prime/Protein-Boost Vaccination Strategy for Eliciting Long-Term, Protective T Cell Immunity against Trypanosoma cruzi,” Plos Pathogens, vol. 11, no. 5, 2015. View at Publisher · View at Google Scholar
  • Hyun Mo Yang, “ A MATHEMATICAL MODEL TO ASSESS THE IMMUNE RESPONSE AGAINST TRYPANOSOMA CRUZI INFECTION ,” Journal of Biological Systems, vol. 23, no. 01, pp. 131–163, 2015. View at Publisher · View at Google Scholar
  • Debora B. Mello, Adriana B. Carvalho, Isalira P. Ramos, Fernanda C. P. Mesquita, Guilherme V. Brasil, Nazareth N. Rocha, Christina M. Takiya, Ana Paula C. A. Lima, Antonio C. Campos de Carvalho, and Regina S. Goldenberg, “Adipose tissue-derived mesenchymal stromal cells protect mice infected with Trypanosoma cruzi from cardiac damage through modulation of anti-parasite immunity,” PLoS Neglected Tropical Diseases, vol. 9, no. 8, 2015. View at Publisher · View at Google Scholar
  • M P Cabral-Piccin, L V C Guillermo, N S Vellozo, A A Filardy, S T Pereira-Marques, T S Rigoni, W F Pereira-Manfro, G A DosReis, and M F Lopes, “Apoptotic CD8 T-lymphocytes disable macrophage-mediated immunity to Trypanosoma cruzi infection,” Cell Death and Disease, vol. 7, no. 5, pp. e2232, 2016. View at Publisher · View at Google Scholar
  • Prajwal Gurung, and Thirumala-Devi Kanneganti, “Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors,” Cellular and Molecular Life Sciences, 2016. View at Publisher · View at Google Scholar
  • Deena Shrestha, Bijay Bajracharya, Guilherme P Costa, Beatriz C Salles, Ana Luísa J Leite, Ana Paula J Menezes, Débora MS Souza, Laser AM Oliveira, and André Talvani, “Expression and production of cardiac angiogenic mediators depend on the Trypanosoma cruzi-genetic population in experimental C57BL/6 mice infection,” Microvascular Research, 2016. View at Publisher · View at Google Scholar
  • Suprabhat Mukherjee, Subhajit Karmakar, and Santi Sinha Babu, “TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review,” The Brazilian Journal of Infectious Diseases, 2016. View at Publisher · View at Google Scholar
  • Mariana S. Cardoso, João Luís Reis-Cunha, and Daniella C. Bartholomeu, “Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection,” Frontiers in Immunology, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Ana-Carolina Oliveira, João Francisco Gomes-Neto, Carlos-Henrique Dantas Barbosa, Alessandra Granato, Bernardo S Reis, Bruno Maia Santos, Rita Fucs, Fábio B Canto, Helder I Nakaya, Alberto Nóbrega, and Maria Bellio, “Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection,” eLife, vol. 6, 2017. View at Publisher · View at Google Scholar
  • Shoko Kitada, Hisako Kayama, Daisuke Okuzaki, Ritsuko Koga, Masao Kobayashi, Yasunobu Arima, Atsushi Kumanogoh, Masaaki Murakami, Masahito Ikawa, and Kiyoshi Takeda, “ BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection ,” The Journal of Experimental Medicine, pp. jem.20161076, 2017. View at Publisher · View at Google Scholar
  • Lisa Yi Liang, Bojlul Bahar, Julio Nuñez-Burgos, Natalia Barrientos, Imran H. Chowdhury, Nisha Jain Garg, Sue-Jie Koo, Shivali Gupta, Laura Silla, and Maria Paola Zago, “Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease,” Journal of Innate Immunity, vol. 9, no. 2, pp. 203–216, 2017. View at Publisher · View at Google Scholar
  • Pamela Cribb, Virginia Perdomo, Victoria L. Alonso, Romina Manarin, Jorge Barrios-Payan, Brenda Marquina-Castillo, Luis Tavernelli, and Rogelio Hernández-Pando, “Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells,” PLOS Neglected Tropical Diseases, vol. 11, no. 2, pp. e0005350, 2017. View at Publisher · View at Google Scholar
  • Luísa M. D. Magalhães, Agostinho Viana, Augusto C. de Jesus, Egler Chiari, Lúcia Galvão, Juliana A. Gomes, Kenneth J. Gollob, and Walderez O. Dutra, “Distinct Trypanosoma cruzi isolates induce activation and apoptosis of human neutrophils,” Plos One, vol. 12, no. 11, pp. e0188083, 2017. View at Publisher · View at Google Scholar
  • Carlos A. Toro Acevedo, Bruna M. Valente, Gabriela A. Burle-Caldas, Bruno Galvão-Filho, Helton da C. Santiago, Rosa M. Esteves Arantes, Caroline Junqueira, Ricardo T. Gazzinelli, Ester Roffê, and Santuza M. R. Teixeira, “Down Modulation of Host Immune Response by Amino Acid Repeats Present in a Trypanosoma cruzi Ribosomal Antigen,” Frontiers in Microbiology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Cecilia Pérez Brandán, Andrea C. Mesías, Cecilia Parodi, Rubén O. Cimino, Carolina Pérez Brandán, Patricio Diosque, and Miguel Ángel Basombrío, “Effects of IFN-γ coding plasmid supplementation in the immune response and protection elicited by Trypanosoma cruzi attenuated parasites,” BMC Infectious Diseases, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Shankar Suman, Girish Rachakonda, Sammed N. Mandape, Shruti S. Sakhare, Fernando Villalta, Siddharth Pratap, Maria F. Lima, and Pius N. Nde, “Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase,” PLOS Neglected Tropical Diseases, vol. 12, no. 9, pp. e0006792, 2018. View at Publisher · View at Google Scholar
  • Rodolfo A Kölliker-Frers, Matilde Otero-Losada, Gabriela Razzitte, Mariela Calvo, Justo Carbajales, and Francisco Capani, “Chagas Cardiomyopathy: Role of Sustained Host-Parasite Interaction in Systemic Inflammatory Burden,” Chagas Disease - Basic Investigations and Challenges, 2018. View at Publisher · View at Google Scholar
  • Luis M. de Pablos Torró, Lissette Retana Moreira, and Antonio Osuna, “Extracellular Vesicles in Chagas Disease: A New Passenger for an Old Disease,” Frontiers in Microbiology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Ana Rosa Pérez, Alexandre Morrot, Vinicius Frias Carvalho, Juliana de Meis, and Wilson Savino, “Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions,” Frontiers in Endocrinology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • João F. Gomes-Neto, Rossella Sartorius, Fábio B. Canto, Thamyres S. Almeida, André A. Dias, Carlos-Henrique D. Barbosa, Guilherme A. Melo, Ana Carolina Oliveira, Pedro-Henrique N. Aguiar, Carlos R. Machado, Herbert L. de Matos Guedes, Marcelo F. Santiago, Alberto Nóbrega, Piergiuseppe De Berardinis, and Maria Bellio, “Vaccination With Recombinant Filamentous fd Phages Against Parasite Infection Requires TLR9 Expression,” Frontiers in Immunology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Amanda Aparecida Felizardo, Débora Vasconcelos Bastos Marques, Ivo Santana Caldas, Reggiani Vilela Gonçalves, and Rômulo Dias Novaes, “Could age and aging change the host response to systemic parasitic infections? A systematic review of preclinical evidence,” Experimental Gerontology, vol. 104, pp. 17–27, 2018. View at Publisher · View at Google Scholar
  • Patrícia E. de Almeida, Daniel A. M. Toledo, Gabriel S. C. Rodrigues, and Heloisa D’Avila, “Lipid Bodies as Sites of Prostaglandin E2 Synthesis During Chagas Disease: Impact in the Parasite Escape Mechanism,” Frontiers in Microbiology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Anusree Mahanta, Piyali Ganguli, Pankaj Barah, Ram Rup Sarkar, Neelanjana Sarmah, Saurav Phukan, Mayuri Bora, and Shashi Baruah, “Integrative Approaches to Understand the Mastery in Manipulation of Host Cytokine Networks by Protozoan Parasites with Emphasis on Plasmodium and Leishmania Species,” Frontiers in Immunology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Junaid Jibran Jawed, Sayantan Banerjee, Syamdas Bandyopadhyay, Shabina Parveen, Bidisha Paul Chowdhury, Prasanta Saini, and Subrata Majumdar, “Immunomodulatory effect of Arabinosylated lipoarabinomannan restrict the progression of visceral leishmaniasis through NOD2 inflammatory pathway: Functional regulation of T cell subsets,” Biomedicine & Pharmacotherapy, vol. 106, pp. 724–732, 2018. View at Publisher · View at Google Scholar