Journal of Parasitology Research / 2012 / Article / Tab 1

Review Article

Host-Parasite Interaction: Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix

Table 1

Extracellular parasite-derived proteases that degrade human ECM proteins.

ParasiteProteasePurifiedGeneTypeECM Substrates Localization Reference

Entamoeba histolytica72 kDa proteaseNoNDNDINDNDNDCrude extracts EDG[33]
Major neutral protease (56 kDa)YesNDCPIYesYesNDND[21]
117, 97, and 68 kDaNoNDNDINDNDNDEDG[35]
EhCP5YesYesCPINDNDNDSecreted[36, 37]
Giardia intestinalis66, 45, 30, and 18 kDaNoNDCPINDNDNDCrude extracts[38]
145, 96, and 82 kDaNoNDCPINDNDNDSecreted[39]
Acanthamoeba spp.70–130 kDaNoNDSPNDNDNDYesSecreted[40]
Acanthamoeba castellanii12 kDaYesYesSPIYesYesNDSecreted[41]
130 kDaNoNDSPI, IIINONOYesSecreted[42]
150 kDaNoNDMMPI, IIINONoYesSecreted[42]
Acanthamoeba healyi 33 kDaYesNDSPI, IVYesNDNDSecreted[43]
Acanthamoeba lugdunensis33 kDaYesNDSPIVYesYesNDSecreted[44]
Naegleria fowleri30 kDaYesNDCPINDNDYesSecreted[45]
Trichomonas vaginalisCP30NoNDCPIVYesNoNDCytoplasm[46]
Cell surface
CP39NoNDCPI, III, IV, VYesNDNDSecreted[47]
Cell surface
Cell surface
Trypanosoma brucei40 kDa neutral metalloproteaseYesNDMMPYesYesYesNDSecreted[49]
GP63 zinc metalloproteaseYesYesMMPINDNDNDCell surface[50, 51]
Cathepsin B (tbCatB)YesYesCPINDNDNDLysosome[54]
POP TbYesYesSPYesNDNDNDReleased into the host blood stream[56]

CPs: cysteine proteases; SPs: serine proteases; ECM: extracellular matrix; ND: not determined; EDG: electron-dense granules; MMPs: matrix metalloproteases; POP: prolyl oligopeptidase.

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