Journal of Parasitology Research / 2012 / Article / Tab 3

Review Article

Host-Parasite Interaction: Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix

Table 3

Intracellular parasite induced proteases that degrade human ECM proteins.

ParasiteProteaseTypeECM substrates Localization Reference

Toxoplasma gondiiMMP-9 or gelatinase BMMPIV, V, XI, XIVNDYesYesInfected macrophage surface and secreted[153, 205207]
MT1-MMP or MMP-14MT-MMPI, II, IIIYesYesNDInfected macrophage surface[153, 204, 205, 208]
MMP-2 or gelatinase AMMPI, II, III, IV, V, VII, X, XIYesYesYesSecreted by unknown host cell[153, 207, 209]
MMP-12 or macrophage elastaseMMP I, IV, VYesYesYesSecreted by unknown host cell[153, 207, 210, 211]
Plasmodium falciparumMMP-9 or gelatinase BMMPIV, V, XI, XIVNDYesYesSecreted by unknown host cell[153, 212]
MMP-8MMPI, II, IIINDNDNDSecreted by unknown host cell[153, 213]

MT1-MMP: membrane-type MMP.

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