Journal of Parasitology Research / 2012 / Article / Tab 3

Review Article

Host-Parasite Interaction: Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix

Table 3

Intracellular parasite induced proteases that degrade human ECM proteins.

ParasiteProteaseTypeECM substrates Localization Reference
CollagenFibronectinLamininElastin

Toxoplasma gondiiMMP-9 or gelatinase BMMPIV, V, XI, XIVNDYesYesInfected macrophage surface and secreted[153, 205207]
MT1-MMP or MMP-14MT-MMPI, II, IIIYesYesNDInfected macrophage surface[153, 204, 205, 208]
MMP-2 or gelatinase AMMPI, II, III, IV, V, VII, X, XIYesYesYesSecreted by unknown host cell[153, 207, 209]
MMP-12 or macrophage elastaseMMP I, IV, VYesYesYesSecreted by unknown host cell[153, 207, 210, 211]
Plasmodium falciparumMMP-9 or gelatinase BMMPIV, V, XI, XIVNDYesYesSecreted by unknown host cell[153, 212]
MMP-8MMPI, II, IIINDNDNDSecreted by unknown host cell[153, 213]

MT1-MMP: membrane-type MMP.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.