TY - JOUR A2 - Lopes, Marcela F. AU - Mendes Wanderley, Joao Luiz AU - Costa, Jaqueline França AU - Borges, Valéria Matos AU - Barcinski, Marcello PY - 2012 DA - 2012/02/02 TI - Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of Phosphatidylserine as a Main Regulator SP - 981686 VL - 2012 AB - Leishmania amazonensis parasites cause progressive disease in most inbred mouse strains and are associated with the development of diffuse cutaneous leishmaniasis in humans. The poor activation of an effective cellular response is correlated with the ability of these parasites to infect mononuclear phagocytic cells without triggering their activation or actively suppressing innate responses of these cells. Here we discuss the possible role of phosphatidylserine exposure by these parasites as a main regulator of the mechanism underlying subversion of the immune system at different steps during the infection. SN - 2090-0023 UR - https://doi.org/10.1155/2012/981686 DO - 10.1155/2012/981686 JF - Journal of Parasitology Research PB - Hindawi Publishing Corporation KW - ER -