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Journal of Parasitology Research
Volume 2013, Article ID 356107, 7 pages
http://dx.doi.org/10.1155/2013/356107
Research Article

The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice

1Department of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, Ghana
2Department of Optometry, School of Physical Sciences, University of Cape Coast, Cape Coast, Ghana
3Department of Biomedical Sciences, Faculty of Sciences, University of Dschang, P.O. Box 067, Dschang, Cameroon
4Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, KNUST, Kumasi, Ghana

Received 2 March 2013; Revised 29 May 2013; Accepted 14 June 2013

Academic Editor: Wej Choochote

Copyright © 2013 J. N. Boampong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana. Xylopic acid, a pure compound isolated from the fruits of the Xylopia aethiopica, was investigated to establish its attributable prophylactic, curative antimalarial, and antipyretic properties. The antimalarial properties were determined by employing xylopic acid (10–100 mg/kg) in ICR mice infected with Plasmodium berghei. Xylopic acid exerted significant ( ) effects on P. berghei infection similar to artemether/lumefantrine, the standard drug. Furthermore, it significantly ( ) reduced the lipopolysaccharide- (LPS-) induced fever in Sprague-Dawley rats similar to prednisolone. Xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent.