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Journal of Parasitology Research
Volume 2013, Article ID 703781, 5 pages
Research Article

Cajachalcone: An Antimalarial Compound from Cajanus cajan Leaf Extract

1Department of Pharmacognosy, University of Ibadan, Ibadan 200284, Nigeria
2Department of Pharmacology & Therapeutics, University of Ibadan, Ibadan 200284, Nigeria
3Department of Biological Sciences, Olabisi Onabanjo University, Ago-Iwoye 110001, Nigeria
4Department of Pharmacy, King’s College London, 150 Stamford Street, London SE1 8WA, UK
5The School of Pharmacy, University of Bradford, West Yorkshire BD7 1DP, UK

Received 4 February 2013; Accepted 16 April 2013

Academic Editor: Wej Choochote

Copyright © 2013 E. O. Ajaiyeoba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cajanus cajan L, a member of the family Fabaceae, was identified from the Nigerian antimalarial ethnobotany as possessing antimalarial properties. The bioassay-guided fractionation of the crude methanol extract of C. cajan leaves was done in vitro using the multiresistant strain of Plasmodium falciparum (K1) in the parasite lactate dehydrogenase assay. Isolation of compound was achieved by a combination of chromatographic techniques, while the structure of the compound was elucidated by spectroscopy. This led to the identification of a cajachalcone, 2′,6′-dihydroxy-4-methoxy chalcone, as the biologically active constituent from the ethyl acetate fraction. Cajachalcone had an IC50 value of 2.0 μg/mL (7.4 μM) and could be a lead for anti-malarial drug discovery.