Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62

Table 1

Differential functional responses of mast cell subsets.

PDMC

Mucosal-type BMMC

CTMC

Basal

Fc𝜀RI

LPS

P/I

Basal

Fc𝜀RI

LPS

P/I

Basal

Fc𝜀RI

LPS

P/I

Degranulation (%)

4.48 ± 0.56

33.24 ± 4.07

2.87 ± 1.47

55.34 ± 4.24

7.46 ± 1.10

17.34 ± 2.19

2.87 ± 1.78

31.97 ± 3.78

3.95 ± 1.02

17.3 ± 2.90

2.173 ± 0.48

25.29 ± 4.62

𝑛=7

𝑛=2

𝑛=4

𝑛=5

𝑛=3

𝑛=5

𝑛=2

𝑛=2

𝑛=2

PGD2 (pg/mL)

1804 ± 44

1907 ± 55

3257 ± 338

4711 ± 264

4509 ± 156

2888 ± 370

3229 ± 333

4764 ± 153

𝑛=3

𝑛=5

𝑛=5

𝑛=5

𝑛=2

IL-6 (pg/mL)

70 ± 27

67 ± 32

81.33 ± 7

408 ± 61

37.4 ± 14.7

560 ± 96

2557 ± 696

21976 ± 6589

87 ± 23

114 ± 19

812 ± 217

𝑛=6

𝑛=4

𝑛=3

𝑛=18

𝑛=18

𝑛=4

𝑛=3

𝑛=4

IL-13 (pg/mL)

7.81 ± 1.52

17.91 ± 2.84

25.91 ± 4.43

248 ± 20

5.88 ± 0.86

366 ± 88

338 ± 116

1578 ± 111

3.94 ± 2.94

18.5 ± 0.45

44.7 ± 1.1

𝑛=6

𝑛=7

𝑛=3

𝑛=6

𝑛=5

𝑛=3

𝑛=1

𝑛=1

MCP-1 (pg/mL)

457 ± 73

387 ± 84

616 ± 109

102 ± 19

504 ± 212

1703 ± 393

862 ± 296

396 ± 58

1410 ± 226

511 ± 76

𝑛=2

𝑛=2

𝑛=3

𝑛=2

𝑛=2

TNF𝛼

15.25 ± 2.48

15.57 ± 2.91

19.62 ± 3.38

32.33 ± 2.94

5.02 ± 2.12

506 ± 159

150 ± 38

3199 ± 916

1.42 ± 0.19

1.41 ± 0.34

15.62 ± 1.61

𝑛=1

𝑛=1

𝑛=12

𝑛=9

𝑛=4

𝑛=1

𝑛=2

Data are presented as the mean values ± SEM where n = number of independent experiments or mean values ± SD of triplicate samples in the case where data from a single experiment are presented.