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Journal of Parasitology Research
Volume 2014 (2014), Article ID 187640, 10 pages
http://dx.doi.org/10.1155/2014/187640
Research Article

Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani

1Department of Biochemistry, University of Calcutta, Kolkata 700019, India
2Department of Civil Engineering, Indian Institute of Technology, Kharagpur 721302, India

Received 14 August 2014; Revised 21 November 2014; Accepted 24 November 2014; Published 31 December 2014

Academic Editor: Barbara Papadopoulou

Copyright © 2014 Sudipta Chakraborty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. D. Ready, “Epidemiology of visceral leishmaniasis,” Clinical Epidemiology, vol. 6, no. 1, pp. 147–154, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Desjeux, “Leishmaniasis: current situation and new perspectives,” Comparative Immunology, Microbiology and Infectious Diseases, vol. 27, no. 5, pp. 305–318, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Lainson, L. Ryan, and J. J. Shaw, “Infective stages of Leishmania in the sandfly vector and some observations on the mechanism of transmission.,” Memorias do Instituto Oswaldo Cruz, vol. 82, no. 3, pp. 421–424, 1987. View at Publisher · View at Google Scholar · View at Scopus
  4. K.-P. Chang, G. Chaudhuri, and D. Fong, “Molecular determinants of Leishmania virulence,” Annual Review of Microbiology, vol. 44, pp. 499–529, 1990. View at Publisher · View at Google Scholar · View at Scopus
  5. Y.-L. Meng, Z. Liu, and B. P. Rosen, “As(III) and Sb(III) uptake by GlpF and efflux by ArsB in Escherichia coli,” Journal of Biological Chemistry, vol. 279, no. 18, pp. 18334–18341, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Dey, M. Ouellette, J. Lightbody, B. Papadopoulou, and B. P. Rosen, “An ATP-dependent as(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 5, pp. 2192–2197, 1996. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Zhou, N. Messier, M. Ouellette, B. P. Rosen, and R. Mukhopadhyay, “Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug Pentostam,” The Journal of Biological Chemistry, vol. 279, no. 36, pp. 37445–37451, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Wyllie, M. L. Cunningham, and A. H. Fairlamb, “Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani,” The Journal of Biological Chemistry, vol. 279, no. 38, pp. 39925–39932, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Mehta and C. Shaha, “Mechanism of metalloid-induced death in Leishmania spp.: role of iron, reactive oxygen species, Ca2+, and glutathione,” Free Radical Biology and Medicine, vol. 40, no. 10, pp. 1857–1868, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Lemarie, C. Morzadec, E. Bourdonnay, O. Fardel, and L. Vernhet, “Human macrophages constitute targets for immunotoxic inorganic arsenic,” The Journal of Immunology, vol. 177, no. 5, pp. 3019–3027, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. H.-Y. Chiou, S.-T. Chiou, Y.-H. Hsu et al., “Incidence of transitional cell carcinoma and arsenic in drinking water: a follow-up study of 8,102 residents in an arseniasis-endemic area in northeastern Taiwan,” The American Journal of Epidemiology, vol. 153, no. 5, pp. 411–418, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Albert, “The covalent bond in selective toxicity,” in Selective Toxicity: Physico-Chemical Basis of Therapy, A. Albert, Ed., chapter 13, pp. 551–555, Chapman & Hall, London, UK, 7th edition, 1985. View at Google Scholar
  13. A. Albert, “Chemotherapy: history and principles,” in Selective Toxicity: Physico-Chemical Basis of Therapy, A. Albert, Ed., chapter 6, pp. 206–219, Chapman & Hall, London, UK, 7th edition, 1985. View at Google Scholar
  14. S. G. Antimisiaris, P. Klepetsanis, V. Zachariou, E. Giannopoulou, and P. V. Ioannou, “In vivo distribution of arsenic after i.p. injection of arsonoliposomes in balb-c mice,” International Journal of Pharmaceutics, vol. 289, no. 1-2, pp. 151–158, 2005. View at Google Scholar
  15. A. J. Thorley and T. D. Tetley, “New perspectives in nanomedicine,” Pharmacology & Therapeutics, vol. 140, no. 2, pp. 176–185, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Curtis and C. Wilkinson, “Nantotechniques and approaches in biotechnology,” Trends in Biotechnology, vol. 19, no. 3, pp. 97–101, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Moreno, J. Schwartz, C. Fernández et al., “Nanoparticles as multifunctional devices for the topical treatment of cutaneous leishmaniasis,” Expert Opinion on Drug Delivery, vol. 11, no. 4, pp. 579–597, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. M. S. Espuelas, P. Legrand, P. M. Loiseau, C. Bories, G. Barratt, and J. M. Irache, “In vitro antileishmanial activity of amphotericin B loaded in poly(ε-caprolactone) nanospheres,” Journal of Drug Targeting, vol. 10, no. 8, pp. 593–599, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. E. C. Torres-Santos Jr., D. L. Moreira, M. A. Kaplan, and B. Rossi-Bergmann, “Improvement of in vitro and in vivo antileishmanial activities of 29,69-dihydroxy-49-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles,” Antimicrobial Agents and Chemotherapy, vol. 43, no. 7, pp. 1776–1778, 1999. View at Google Scholar
  20. J. M. Rodrigues Jr., S. L. Croft, H. Fessi, C. Bories, and J.-P. Devissguet, “The activity and ultrastructural localization of primaquine-loaded poly (d, l-lactide) nanoparticles in Leishmania donovani infected mice,” Tropical Medicine and Parasitology, vol. 45, no. 3, pp. 223–228, 1994. View at Google Scholar · View at Scopus
  21. A. M. Allahverdiyev, E. S. Abamor, M. Bagirova et al., “Investigation of antileishmanial activities of TiO2@Ag nanoparticles on biological properties of L. tropica and L. infantum parasites, in vitro,” Experimental Parasitology, vol. 135, no. 1, pp. 55–63, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. A. M. Allahverdiyev, E. S. Abamor, M. Bagirova et al., “Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light,” International Journal of Nanomedicine, vol. 6, pp. 2705–2714, 2011. View at Google Scholar · View at Scopus
  23. A. Jebali and B. Kazemi, “Nano-based antileishmanial agents: a toxicological study on nanoparticles for future treatment of cutaneous leishmaniasis,” Toxicology in Vitro, vol. 27, no. 6, pp. 1896–1904, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Pal, S. Saha, S. K. Maji, M. Kundu, and A. Kundu, “Wet-chemical synthesis of spherical arsenic nanoparticles by a simple reduction method and its characterization,” Advanced Materials Letters, vol. 3, no. 3, pp. 177–180, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Paik, P. Das, T. De, and T. Chakraborti, “In vitro anti-leishmanial efficacy of potato tuber extract (PTEx): leishmanial serine protease(s) as putative target,” Experimental Parasitology, vol. 146, pp. 11–19, 2014. View at Publisher · View at Google Scholar
  26. G. M. Kapler, C. M. Coburn, and S. M. Beverley, “Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expression,” Molecular and Cellular Biology, vol. 10, no. 3, pp. 1084–1094, 1990. View at Google Scholar · View at Scopus
  27. K. R. Santhamma and A. Bhaduri, “Characterization of the respiratory chain of Leishmania donovani promastigotes,” Molecular and Biochemical Parasitology, vol. 75, no. 1, pp. 43–53, 1995. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Ukil, A. Biswas, T. Das, and P. K. Das, “18β-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-κB,” Journal of Immunology, vol. 175, no. 2, pp. 1161–1169, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. B. P. Rosen, “Biochemistry of arsenic detoxification,” FEBS Letters, vol. 529, no. 1, pp. 86–92, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. O. M. N. Dhubhghaill and P. J. Sadler, “The structure and reactivity of arsenic compounds: biological activity and drug design,” Bioinorganic Chemistry Structure and Bonding, vol. 78, pp. 129–190, 1991. View at Google Scholar