Research Article

Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani

Table 2

(a) Inhibition of parasite infection (at 37°C for 24 hours). (b) Inhibition of parasite attachment (at 4°C for 4 hours).
(a)

SetsTotal number of macrophagesNumbers of infected macrophagesNumbers of internalized parasites inside the macrophages

Control500
2 M As-NP500
0.1 M As (III)500
1.0 M As (III)500
2 M As (III)500

values for number of infected macrophages and internalized parasites are 0.001 which is statistically significant.
(b)

SetsTotal number of macrophagesNumbers of infected macrophagesNumbers of attached parasites in the surface of macrophages

Control20052#68#
2 M As-NP20022#23#

values for number of infected macrophages and attached parasites are 0.0014 which is statistically significant.