A Brief View of the Surface Membrane Proteins from Trypanosoma cruzi

Table 1

Summary of surface protein families of Trypanosoma cruzi and their characteristics.

Protein Family	Group	Members	Host	Parasite stage	References
Mucin	TcMUC	TcMUC I	Mammal	Amastigote and bloodstream trypomastigote	[29]
		TcMUC II	Mammal	Amastigote and bloodstream trypomastigote	[30, 31]
		TcMUC III (TSSA)	Mammal	Bloodstream trypomastigote	[30]
	TcSMUG	TcSMUG S	Insect	Epimastigote and metacyclic trypomastigote	[30, 32, 33]
		TcSMUG L	Insect	Epimastigote	[34, 35]
Trans-sialidase	TS I	TCNA	Mammal	Bloodstream trypomastigote	[36–38]
		SAPA	Mammal	Bloodstream trypomastigote	[38]
		TS-epi	Insect	Epimastigote	[39]
	TS II	ASP-1 and ASP-2	Mammal	Amastigote	[40, 41]
		TSA-1, Tc85, and SA85	Mammal	Bloodstream trypomastigote	[42–44]
		GP82	Insect	Metacyclic trypomastigote	[45]
		GP90	Insect/mammal	Amastigote, bloodstream and metacyclic trypomastigote	[10, 46, 47]
	TS III	CRP, FL160, CEA, and TESA	Mammal	Bloodstream trypomastigote	[48]
	TS IV	TsTc13	Insect	Metacyclic trypomastigote	[49]
TcGP63 family	TcGP63-I	61 kDa glycosylated isoform	Insect/Mammal	Epimastigote and amastigote	[50, 51]
		55 kDa nonglycosylated protein	Insect	Metacyclic trypomastigote	[50, 51]
	TcGP63-II	Two transcripts of 2.6 and 2.8 kb	Insect/mammal	Amastigotes, epimastigote, and bloodstream trypomastigote	[50, 52]
Amastin family	δ-Amastins	δ-Amastin and δ-ama40/50	Mammal	Present in all life cycle, up-regulated in amastigotes stage	[53]
	β-Amastin	β1-Amastin and β2-amastin	Insect/mammal	Present in all life cycle, upregulated in epimastigote stage	[53]
TcTASV family	TcTASV-A		Mammal	Bloodstream trypomastigote	[54]
	TcTASV-B		Mammal	Bloodstream trypomastigote	[54]
	TcTASV-C		Mammal	Bloodstream trypomastigote	[55]
MASP family			Insect/mammal	Amastigote, epimastigote, bloodstream and metacyclic trypomastigote
Cruzipain family	N-cruzipain		Insect	Epimastigote	[56, 57]
	R-cruzipain 1 (cruzain)		Insect/mammal	Epimastigote, bloodstream trypomastigote and amastigote	[58, 59]
	R-cruzipain 2		Mammal	Bloodstream trypomastigote and amastigote	[56]