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Journal of Parasitology Research
Volume 2017, Article ID 5056314, 13 pages
https://doi.org/10.1155/2017/5056314
Review Article

Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research

Department of Animal Biology, Post-Graduation Program in Animal Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil

Correspondence should be addressed to Danilo Ciccone Miguel; rb.pmacinu@leugimcd and Silmara Marques Allegretti; rb.pmacinu@ergellas

Received 25 October 2016; Accepted 8 December 2016; Published 22 January 2017

Academic Editor: D. S. Lindsay

Copyright © 2017 Tiago Mendes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Puthiyakunnon, S. Boddu, Y. Li et al., “Strongyloidiasis—an insight into its global prevalence and management,” PLoS Neglected Tropical Diseases, vol. 8, no. 8, Article ID e3018, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. H. J. Dawkins and D. I. Grove, “Attempts to establish infections with Strongyloides stercoralis in mice and other laboratory animals,” Journal of Helminthology, vol. 56, no. 1, pp. 23–26, 1982. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Beknazarova, H. Whiley, and K. Ross, “Strongyloidiasis: a disease of socioeconomic disadvantage,” International Journal of Environmental Research and Public Health, vol. 13, no. 5, article 517, 2016. View at Publisher · View at Google Scholar
  4. A. L. R. Gonçalves, K. C. L. de Araújo, E. F. G. Carvalho, M. T. Ueta, and J. M. Costa-Cruz, “Specific IgG and immune complex responses to parthenogenetic females and eggs of nematode Strongyloides venezuelensis for the diagnosis of immunosuppression in infected rats,” Journal of Helminthology, vol. 90, no. 3, pp. 342–346, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. D. R. Herbert, J. J. Lee, N. A. Lee, T. J. Nolan, G. A. Schad, and D. Abraham, “Role of IL-5 in innate and adaptive immunity to larval Strongyloides stercoralis in mice,” The Journal of Immunology, vol. 165, no. 8, pp. 4544–4551, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Boscolo, M. Gobbo, W. Mantovani et al., “Evaluation of an indirect immunofluorescence assay for strongyloidiasis as a tool for diagnosis and follow-up,” Clinical and Vaccine Immunology, vol. 14, no. 2, pp. 129–133, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. L. A. Chaves, A. L. R. Gonçalves, F. M. Paula et al., “Comparison of parasitological, immunological and molecular methods for evaluation of fecal samples of immunosuppressed rats experimentally infected with Strongyloides venezuelensis,” Parasitology, vol. 142, no. 14, pp. 1715–1721, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Gomez-Junyent, D. Paredes-Zapata, E. R. de Las Parras et al., “Real-time polymerase chain reaction in stool detects transmission of Strongyloides stercoralis from an infected donor to solid organ transplant recipients,” The American Journal of Tropical Medicine and Hygiene, vol. 94, no. 4, pp. 897–899, 2016. View at Publisher · View at Google Scholar
  9. A. L. R. Gonçalves, G. A. Machado, M. R. F. Gonçalves-Pires, A. Ferreira-Júnior, D. A. O. Silva, and J. M. Costa-Cruz, “Evaluation of strongyloidiasis in kennel dogs and keepers by parasitological and serological assays,” Veterinary Parasitology, vol. 147, no. 1-2, pp. 132–139, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. D. I. Grove, C. Northern, and P. J. Heenan, “Strongyloides stercoralis infections in the muscles of mice: a model for investigating the systemic phase of strongyloidiasis,” Pathology, vol. 18, no. 1, pp. 72–76, 1986. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Alsharif, A. Sodhi, L. C. Murillo, A. S. Headley, and D. Kadaria, “Wait!!! No steroids for this asthma,” American Journal of Case Reports, vol. 16, pp. 398–400, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. E. A. Rodriguez, T. Abraham, and F. K. Williams, “Severe strongyloidiasis with negative serology after corticosteroid treatment,” American Journal of Case Reports, vol. 16, pp. 95–98, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. M. L. S. Silva, E. J. Inês, A. B. S. Souza et al., “Association between Strongyloides stercoralis infection and cortisol secretion in alcoholic patients,” Acta Tropica, vol. 154, pp. 133–138, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Montes, C. Sanchez, K. Verdonck et al., “Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen,” PLoS Neglected Tropical Diseases, vol. 3, article e456, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. W. A. Martins, A. L. Melo, J. R. Nicoli et al., “A method of decontaminating Strongyloides venezuelensis larvae for the study of strongyloidiasis in germ-free and conventional mice,” Journal of Medical Microbiology, vol. 49, no. 4, pp. 387–390, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. A. L. Legarda-Ceballos, J. López-Abán, E. Del Olmo et al., “In vitro and in vivo evaluation of 2-aminoalkanol and 1,2-alkanediamine derivatives against Strongyloides venezuelensis,” Parasites & Vectors, vol. 9, article 364, 2016. View at Publisher · View at Google Scholar
  17. J. Keiser, K. Thiemann, Y. Endriss, and J. Utzinger, “Strongyloides ratti: in vitro and in vivo activity of tribendimidine,” PLoS Neglected Tropical Diseases, vol. 2, no. 1, article e136, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. J. B. Lok, “Strongyloides stercoralis: a model for translational research on parasitic nematode biology,” WormBook, pp. 1–18, 2007. View at Google Scholar · View at Scopus
  19. P. Sithithaworn, Y. Fujimaki, Y. Mitsui, R. Prasanthong, W. Yutanawiboonchai, and Y. Aoki, “Efficacy of ivermectin against Strongyloides stercoralis infection in Jirds (Meriones unguiculatus),” Experimental Parasitology, vol. 89, no. 2, pp. 205–212, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. A. C. Kotze, S. Clifford, J. O'Grady, J. M. Behnke, and J. S. Mccarthy, “An in vitro larval motility assay to determine anthelmintic sensitivity for human hookworm and Strongyloides species,” American Journal of Tropical Medicine and Hygiene, vol. 71, no. 5, pp. 608–616, 2004. View at Google Scholar · View at Scopus
  21. D. R. Herbert, T. J. Nolan, G. A. Schad, S. Lustigman, and D. Abraham, “Immunoaffinity-isolated antigens induce protective immunity against larval Strongyloides stercoralis in mice,” Experimental Parasitology, vol. 100, no. 2, pp. 112–120, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. P. A. Olounladé, E. V. B. Azando, M. S. Hounzangbé-Adoté et al., “In vitro anthelmintic activity of the essential oils of Zanthoxylum zanthoxyloides and Newbouldia laevis against Strongyloides ratti,” Parasitology Research, vol. 110, no. 4, pp. 1427–1433, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. T. J. Nolan, Z. Megyeri, V. M. Bhopale, and G. A. Schad, “Strongyloides stercoralis: the first rodent model for uncomplicated and hyperinfective strongyloidiasis, the Mongolian Gerbil (Meriones unguiculatus),” Journal of Infectious Diseases, vol. 168, no. 6, pp. 1479–1484, 1993. View at Publisher · View at Google Scholar · View at Scopus
  24. P. M. Intapan, T. K. Prasongdee, P. Laummaunwai, K. Sawanyawisuth, S. Singthong, and W. Maleewong, “Short report: a modified filter paper culture technique for screening of Strongyloides stercoralis ivermectin sensitivity in clinical specimens,” American Journal of Tropical Medicine and Hygiene, vol. 75, no. 3, pp. 563–564, 2006. View at Google Scholar · View at Scopus
  25. T. Boonmars, W. Khunkitti, P. Sithithaworn, and Y. Fujimaki, “In vitro antiparasitic activity of extracts of Cardiospermum halicacabum against third-stage larvae of Strongyloides stercoralis,” Parasitology Research, vol. 97, no. 5, pp. 417–419, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. W. M. Forbes, W. A. Gallimore, A. Mansingh, P. B. Reese, and R. D. Robinson, “Eryngial (trans-2-dodecenal), a bioactive compound from Eryngium foetidum: its identification, chemical isolation, characterization and comparison with ivermectin in vitro,” Parasitology, vol. 141, no. 2, pp. 269–278, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Tritten, A. Silbereisen, and J. Keiser, “In vitro and in vivo efficacy of monepantel (AAD 1566) against laboratory models of human intestinal nematode infections,” PLoS Neglected Tropical Diseases, vol. 5, no. 12, Article ID e1457, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. C. O. Carvalho, A. C. S. Chagas, F. Cotinguiba et al., “The anthelmintic effect of plant extracts on Haemonchus contortus and Strongyloides venezuelensis,” Veterinary Parasitology, vol. 183, no. 3-4, pp. 260–268, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. Bisoffi, D. Buonfrate, A. Montresor et al., “Strongyloides stercoralis: a plea for action,” PLoS Neglected Tropical Diseases, vol. 7, no. 5, Article ID e2214, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Panic, U. Duthaler, B. Speich, and J. Keiser, “Repurposing drugs for the treatment and control of helminth infections,” International Journal for Parasitology: Drugs and Drug Resistance, vol. 4, no. 3, pp. 185–200, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. V. Luvira, D. Watthanakulpanich, and P. Pittisuttithum, “Management of Strongyloides stercoralis: a puzzling parasite,” International Health, vol. 6, no. 4, pp. 273–281, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. D. M. Stewart, R. Ramanathan, S. Mahanty, D. P. Fedorko, J. E. Janik, and J. C. Morris, “Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma,” Acta Haematologica, vol. 126, no. 2, pp. 63–67, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. P. R. S. Lagacé-Wiens and G. K. M. Harding, “A Canadian immigrant with coinfection of Strongyloides stercoralis and human T-lymphotropic virus 1,” CMAJ, vol. 177, no. 5, pp. 451–453, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Ratner, C. Grant, B. Zimmerman et al., “Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia,” American Journal of Hematology, vol. 82, no. 10, pp. 929–931, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Janssen, E. G. Rossatanga, S. Jurriaans, I. J. M. ten Berge, and M. P. Grobusch, “Triple infection with HIV-1, HTLV-1 and Strongyloides stercoralis, rendering CD4+ T-cell counts a misleading entity,” Antiviral Therapy, vol. 18, no. 7, pp. 949–951, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Hindy, R. Parvin, K. Hanna, and F. Gress, “Strongyloidiasis presenting as duodenal obstruction in a patient infected with human T-cell lymphotropic virus type 1,” Gastrointestinal Endoscopy, vol. 74, no. 2, pp. 439–441, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. T. Kinjo, D. Nabeya, H. Nakamura et al., “Acute respiratory distress syndrome due to Strongyloides stercoralis infection in a patient with cervical cancer,” Internal Medicine, vol. 54, no. 1, pp. 83–87, 2015. View at Publisher · View at Google Scholar · View at Scopus
  38. J. E. Weatherhead and R. Mejia, “Immune response to infection with Strongyloides stercoralis in patients with infection and hyperinfection,” Current Tropical Medicine Reports, vol. 1, no. 4, pp. 229–233, 2014. View at Publisher · View at Google Scholar
  39. M. A. F. Porto, A. Muniz, J. Oliveira Júnior, and E. M. Carvalho, “Implicações clínicas e imunológicas da associação entre o HTLV-1 e a estrongiloidíase,” Revista da Sociedade Brasileira de Medicina Tropical, vol. 35, pp. 641–649, 2002. View at Google Scholar
  40. E. B. Kia, H. R. Rahimi, H. Mirhendi et al., “A case of fatal strongyloidiasis in a patient with chronic lymphocytic leukemia and molecular characterization of the isolate,” Korean Journal of Parasitology, vol. 46, no. 4, pp. 261–263, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. M. P. Zago-Gomes, K. F. Aikawa, S. F. Perazzio, C. S. Gonçalves, and F. E. L. Pereira, “Prevalence of intestinal nematodes in alcoholic patients,” Revista da Sociedade Brasileira de Medicina Tropical, vol. 35, no. 6, pp. 571–574, 2002. View at Publisher · View at Google Scholar · View at Scopus
  42. F. A. Abanyie, E. B. Gray, K. W. Delli Carpini et al., “Donor-derived strongyloides stercoralis infection in solid organ transplant recipients in the United States, 2009–2013,” American Journal of Transplantation, vol. 15, no. 5, pp. 1369–1375, 2015. View at Publisher · View at Google Scholar · View at Scopus
  43. B. A. Abdalhamid, A. N. A. M. Al Abadi, M. I. Al Saghier, A. A. Joudeh, M. A. Shorman, and S. S. Amr, “Strongyloides stercoralis infection in kidney transplant recipients,” Saudi Journal of Kidney Diseases and Transplantation, vol. 26, no. 1, pp. 98–102, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. R. Agarwala, J. Wasielewski, and B. Biman, “Pulmonary strongyloidiasis following renal transplantation without travel to an endemic area,” Oxford Medical Case Reports, vol. 2014, no. 4, pp. 83–85, 2014. View at Publisher · View at Google Scholar
  45. C. Arango, C. Arango, and C. Seas, “Images in clinical tropical medicine: a 29-year-old renal transplant recipient with acute respiratory failure,” American Journal of Tropical Medicine and Hygiene, vol. 86, no. 6, pp. 911–912, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. M. V. Batista, L. C. Pierrotti, E. Abdala et al., “Endemic and opportunistic infections in Brazilian solid organ transplant recipients,” Tropical Medicine and International Health, vol. 16, no. 9, pp. 1134–1142, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. L. O. Coster, “Parasitic infections in solid organ transplant recipients,” Infectious Disease Clinics of North America, vol. 27, no. 2, pp. 395–427, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. C. J. A. Ferreira, D. A. da Silva, P. H. Almeida et al., “Fatal disseminated strongyloidiasis after kidney transplantation,” Revista da Sociedade Brasileira de Medicina Tropical, vol. 45, no. 5, pp. 652–654, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. K. W. Hamilton, P. L. Abt, M. A. Rosenbach et al., “Donor-derived Strongyloides stercoralis infections in renal transplant recipients,” Transplantation, vol. 91, no. 9, pp. 1019–1024, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. C. N. Hsu, S. H. Tseng, S. W. Chang, and Y. Chen, “Strongyloides stercoralis infection in an intestinal transplant recipient,” Transplant Infectious Disease, vol. 15, no. 4, pp. E139–E143, 2013. View at Publisher · View at Google Scholar · View at Scopus
  51. A. P. Iori, A. Ferretti, G. Gentile et al., “Strongyloides stercoralis infection in allogeneic stem cell transplant: a case report and review of the literature,” Transplant Infectious Disease, vol. 16, no. 4, pp. 625–630, 2014. View at Publisher · View at Google Scholar · View at Scopus
  52. H. Issa, M. A. Aljama, and A. H. Al-Salem, “Strongyloides stercoralis hyperinfection in a post-renal transplant patient,” Clinical and Experimental Gastroenterology, vol. 4, no. 1, pp. 269–271, 2011. View at Google Scholar · View at Scopus
  53. I. Izquierdo, J. Briones, R. Lluch, C. Arqueros, and R. Martino, “Fatal Strongyloides hyperinfection complicating a gram-negative sepsis after allogeneic stem cell transplantation: a case report and review of the literature,” Case Reports in Hematology, vol. 2013, Article ID 860976, 5 pages, 2013. View at Publisher · View at Google Scholar
  54. M. S. Khuroo, “Hyperinfection strongyloidiasis in renal transplant recipients,” BMJ Case Reports, 2014. View at Publisher · View at Google Scholar
  55. M. Le, K. Ravin, A. Hasan et al., “Single donor-derived strongyloidiasis in three solid organ transplant recipients: case series and review of the literature,” American Journal of Transplantation, vol. 14, no. 5, pp. 1199–1206, 2014. View at Publisher · View at Google Scholar · View at Scopus
  56. V. Pochineni, D. Lal, S. Hasnayen, and E. Restrepo, “Fatal Strongyloides hyperinfection syndrome in an immunocompromised patient,” American Journal of Case Reports, vol. 16, pp. 603–605, 2015. View at Publisher · View at Google Scholar · View at Scopus
  57. B. Chokkalingam Mani, M. Mathur, H. Clauss et al., “Strongyloides stercoralis and organ transplantation,” Case Reports in Transplantation, vol. 2013, Article ID 549038, 6 pages, 2013. View at Publisher · View at Google Scholar
  58. V. Luvira, K. Trakulhun, M. Mungthin et al., “Comparative diagnosis of strongyloidiasis in immunocompromised patients,” The American Journal of Tropical Medicine and Hygiene, vol. 95, no. 2, pp. 401–404, 2016. View at Publisher · View at Google Scholar
  59. P. Steinmann, X.-N. Zhou, Z.-W. Du et al., “Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial,” PLoS Neglected Tropical Diseases, vol. 2, no. 10, article e322, 2008. View at Publisher · View at Google Scholar · View at Scopus
  60. D. Buonfrate, F. Formenti, F. Perandin, and Z. Bisoffi, “Novel approaches to the diagnosis of Strongyloides stercoralis infection,” Clinical Microbiology and Infection, vol. 21, no. 6, pp. 543–552, 2015. View at Publisher · View at Google Scholar · View at Scopus
  61. M. Montes, C. Sawhney, and N. Barros, “Strongyloides stercoralis: there but not seen,” Current Opinion in Infectious Diseases, vol. 23, no. 5, pp. 500–504, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. M. Sharifdini, H. Mirhendi, K. Ashrafi et al., “Comparison of nested polymerase chain reaction and real-time polymerase chain reaction with parasitological methods for detection of Strongyloides stercoralis in human fecal samples,” The American Journal of Tropical Medicine and Hygiene, vol. 93, no. 6, pp. 1285–1291, 2015. View at Publisher · View at Google Scholar · View at Scopus
  63. C. D. Ericsson, R. Steffen, A. A. Siddiqui, and S. L. Berk, “Diagnosis of Strongyloides stercoralis infection,” Clinical Infectious Diseases, vol. 33, no. 7, pp. 1040–1047, 2001. View at Publisher · View at Google Scholar · View at Scopus
  64. T. Arakaki, M. Iwanaga, F. Kinjo, A. Saito, R. Asato, and T. Ikeshiro, “Efficacy of agar-plate culture in detection of Strongyloides stercoralis infection,” Journal of Parasitology, vol. 76, no. 3, pp. 425–428, 1990. View at Publisher · View at Google Scholar · View at Scopus
  65. T. Hirata, H. Nakamura, N. Kinjo et al., “Increased detection rate of Strongyloides stercoralis by repeated stool examinations using the agar plate culture method,” The American Journal of Tropical Medicine and Hygiene, vol. 77, no. 4, pp. 683–684, 2007. View at Google Scholar · View at Scopus
  66. M. Attia, K. Kamal, M. A. Fouad, M. H. Saleh, and M. Abo-Sabe, “Direct and indirect diagnosis of strongyloidiasis,” Journal of the Egyptian Society of Parasitology, vol. 22, no. 1, pp. 115–119, 1992. View at Google Scholar · View at Scopus
  67. Z. Bisoffi, D. Buonfrate, M. Sequi et al., “Diagnostic accuracy of five serologic tests for Strongyloides stercoralis infection,” PLoS Neglected Tropical Diseases, vol. 8, no. 1, Article ID e2640, 2014. View at Publisher · View at Google Scholar · View at Scopus
  68. D. Buonfrate, M. Sequi, R. Mejia et al., “Accuracy of five serologic tests for the follow up of Strongyloides stercoralis infection,” PLoS Neglected Tropical Diseases, vol. 9, no. 2, Article ID e0003491, 2015. View at Publisher · View at Google Scholar · View at Scopus
  69. H. T. Gonzaga, V. S. Ribeiro, N. D. Feliciano et al., “IgG avidity in differential serodiagnosis of human strongyloidiasis active infection,” Immunology Letters, vol. 139, no. 1-2, pp. 87–92, 2011. View at Publisher · View at Google Scholar · View at Scopus
  70. M. C. Huaman, Y. Sato, J. L. Aguilar et al., “Gelatin particle indirect agglutination and enzyme-linked immunosorbent assay for diagnosis of strongyloidiasis using Strongyloides venezuelensis antigen,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 97, no. 5, pp. 535–538, 2003. View at Publisher · View at Google Scholar · View at Scopus
  71. A. F. Júnior, M. R. F. Gonçalves-Pires, D. A. O. Silva, A. L. R. Gonçalves, and J. M. Costa-Cruz, “Parasitological and serological diagnosis of Strongyloides stercoralis in domesticated dogs from southeastern Brazil,” Veterinary Parasitology, vol. 136, no. 2, pp. 137–145, 2006. View at Publisher · View at Google Scholar · View at Scopus
  72. S. Koosha, M. Fesharaki, and M. B. Rokni, “Comparison of enzyme-linked immunosorbent assay and indirect immunofluorescence assay in the diagnosis of human strongyloidiasis,” Indian Journal of Gastroenterology, vol. 23, no. 6, pp. 214–216, 2004. View at Google Scholar · View at Scopus
  73. D. M. L. Mota-Ferreira, M. D. R. F. Gonçalves-Pires, Á. F. Júnior, M. C. Sopelete, V. O. S. Abdallah, and J. M. Costa-Cruz, “Specific IgA and IgG antibodies in paired serum and breast milk samples in human strongyloidiasis,” Acta Tropica, vol. 109, no. 2, pp. 103–107, 2009. View at Publisher · View at Google Scholar · View at Scopus
  74. W. A. Page, K. Dempsey, and J. S. McCarthy, “Utility of serological follow-up of chronic strongyloidiasis after anthelminthic chemotherapy,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 11, pp. 1056–1062, 2006. View at Publisher · View at Google Scholar · View at Scopus
  75. B. J. Pak, F. Vasquez-Camargo, E. Kalinichenko et al., “Development of a rapid serological assay for the diagnosis of strongyloidiasis using a novel diffraction-based biosensor technology,” PLoS Neglected Tropical Diseases, vol. 8, no. 8, Article ID e3002, 2014. View at Publisher · View at Google Scholar · View at Scopus
  76. Y. Sato, J. Kobayashi, and Y. Shiroma, “Serodiagnosis of strongyloidiasis. The application and significance,” Revista do Instituto de Medicina Tropical de Sao Paulo, vol. 37, no. 1, pp. 35–41, 1995. View at Google Scholar · View at Scopus
  77. L. R. Bosqui, A. L. R. Gonçalves, M. D. R. F. Gonçalves-Pires et al., “Detection of parasite-specific IgG and IgA in paired serum and saliva samples for diagnosis of human strongyloidiasis in northern Paraná state, Brazil,” Acta Tropica, vol. 150, pp. 190–195, 2015. View at Publisher · View at Google Scholar · View at Scopus
  78. E. F. G. de Carvalho, J. E. N. de Sousa, A. L. R. Gonçalves, J. P. da Cunha-Junior, and J. M. Costa-Cruz, “Immunoblotting using Strongyloides venezuelensis larvae, parthenogenetic females or eggs extracts for the diagnosis of experimentally infected immunosuppressed rats,” Experimental Parasitology, vol. 157, pp. 117–123, 2015. View at Publisher · View at Google Scholar · View at Scopus
  79. S. L. Becker, N. Piraisoody, S. Kramme et al., “Real-time PCR for detection of Strongyloides stercoralis in human stool samples from Côte d'Ivoire: diagnostic accuracy, inter-laboratory comparison and patterns of hookworm co-infection,” Acta Tropica, vol. 150, pp. 210–217, 2015. View at Publisher · View at Google Scholar · View at Scopus
  80. F. M. Paula, R. B. Sitta, F. M. Malta et al., “Parasitological and molecular diagnosis in experimental Strongyloides venezuelensis infection,” Revista do Instituto de Medicina Tropical de São Paulo, vol. 55, no. 2, pp. 141–143, 2013. View at Publisher · View at Google Scholar · View at Scopus
  81. S. L. Becker, J. K. Chatigre, J.-P. Gohou et al., “Combined stool-based multiplex PCR and microscopy for enhanced pathogen detection in patients with persistent diarrhoea and asymptomatic controls from Côte d'Ivoire,” Clinical Microbiology and Infection, vol. 21, no. 6, pp. 591.e1–591.e10, 2015. View at Publisher · View at Google Scholar · View at Scopus
  82. P. D. Marques, F. M. Malta, D. M. C. L. Meisel et al., “Diagnosis of the strongyloid nematode Strongyloides venezuelensis in experimentally infected rats,” Journal of Helminthology, vol. 90, pp. 422–427, 2016. View at Publisher · View at Google Scholar · View at Scopus
  83. E. Nadir, T. Grossman, P. Ciobotaro et al., “Real-time PCR for Strongyloides stercoralis-associated meningitis,” Diagnostic Microbiology and Infectious Disease, vol. 84, no. 3, pp. 197–199, 2016. View at Publisher · View at Google Scholar · View at Scopus
  84. F. M. de Paula, F. D. M. Malta, P. D. Marques et al., “Molecular diagnosis of strongyloidiasis in tropical areas: a comparison of conventional and real-time polymerase chain reaction with parasitological methods,” Memorias do Instituto Oswaldo Cruz, vol. 110, no. 2, pp. 272–274, 2015. View at Publisher · View at Google Scholar · View at Scopus
  85. S. A. Repetto, C. D. A. Soto, S. I. Cazorla et al., “An improved DNA isolation technique for PCR detection of Strongyloides stercoralis in stool samples,” Acta Tropica, vol. 126, no. 2, pp. 110–114, 2013. View at Publisher · View at Google Scholar · View at Scopus
  86. S. A. Repetto, P. Ruybal, M. E. Solana et al., “Comparison between PCR and larvae visualization methods for diagnosis of Strongyloides stercoralis out of endemic area: a proposed algorithm,” Acta Tropica, vol. 157, pp. 169–177, 2016. View at Publisher · View at Google Scholar · View at Scopus
  87. J. M. Saugar, F. J. Merino, P. Martín-Rabadán et al., “Application of real-time PCR for the detection of Strongyloides spp. in clinical samples in a reference center in Spain,” Acta Tropica, vol. 142, pp. 20–25, 2015. View at Publisher · View at Google Scholar · View at Scopus
  88. F. Schär, P. Odermatt, V. Khieu et al., “Evaluation of real-time PCR for Strongyloides stercoralis and hookworm as diagnostic tool in asymptomatic schoolchildren in Cambodia,” Acta Tropica, vol. 126, no. 2, pp. 89–92, 2013. View at Publisher · View at Google Scholar · View at Scopus
  89. R. B. Sitta, F. M. Malta, J. R. Pinho, P. P. Chieffi, R. C. B. Gryschek, and F. M. Paula, “Conventional PCR for molecular diagnosis of human strongyloidiasis,” Parasitology, vol. 141, no. 5, pp. 716–721, 2014. View at Publisher · View at Google Scholar · View at Scopus
  90. S. St Cyr, A. Nagpal, and M. R. I. Sohail, “Shiga toxin producing E coli bloodstream infection secondary to Strongyloides penetration through intestinal mucosa,” BMJ Case Reports, vol. 2013, 2013. View at Publisher · View at Google Scholar · View at Scopus
  91. Y. Sultana, N. Jeoffreys, M. R. Watts, G. L. Gilbert, and R. Lee, “Real-time polymerase chain reaction for detection of Strongyloides stercoralis in stool,” The American Journal of Tropical Medicine and Hygiene, vol. 88, no. 6, pp. 1048–1051, 2013. View at Publisher · View at Google Scholar · View at Scopus
  92. M. Z. Abdelrahman, M. Zeehaida, N. Rahmah et al., “Fatal septicemic shock associated with Strongyloides stercoralis infection in a patient with angioimmunoblastic T-cell lymphoma: a case report and literature review,” Parasitology International, vol. 61, no. 3, pp. 508–511, 2012. View at Publisher · View at Google Scholar · View at Scopus
  93. K. Chunlertrith, A. Noiprasit, C. Kularbkaew, O. Sanpool, W. Maleewong, and P. M. Intapan, “A complicated case of strongyloidiasis presenting with intestinal lymphadenopathy obstruction: molecular identification,” Southeast Asian Journal of Tropical Medicine and Public Health, vol. 46, no. 1, pp. 1–7, 2015. View at Google Scholar · View at Scopus
  94. A. N. Seo, Y.-K. Goo, D.-I. Chung, Y. Hong, O. Kwon, and H.-I. Bae, “Comorbid gastric adenocarcinoma and gastric and duodenal Strongyloides stercoralis infection: a case report,” Korean Journal of Parasitology, vol. 53, no. 1, pp. 95–99, 2015. View at Publisher · View at Google Scholar · View at Scopus
  95. E. J. Won, J. Jeon, Y.-I. Koh, and D. W. Ryang, “Strongyloidiasis in a diabetic patient accompanied by gastrointestinal stromal tumor: cause of eosinophilia unresponsive to steroid therapy,” Korean Journal of Parasitology, vol. 53, no. 2, pp. 223–226, 2015. View at Publisher · View at Google Scholar · View at Scopus
  96. S. Bonne-Anneé, J. A. Hess, and D. Abraham, “Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model,” Immunologic Research, vol. 51, no. 2-3, pp. 205–214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  97. Y. Sato and H. Toma, “Strongyloides venezuelensis infections in mice,” International Journal for Parasitology, vol. 20, no. 1, pp. 57–62, 1990. View at Publisher · View at Google Scholar · View at Scopus
  98. G. Wertheim, “Experimental concurrent infections with Strongyloides ratti and S. venezuelensis in laboratory rats,” Parasitology, vol. 61, no. 3, pp. 389–395, 1970. View at Publisher · View at Google Scholar · View at Scopus
  99. D. I. Grove, Strongyloidiasis: A Major Roundworm Infection of Man, Taylor & Francis, 1989.
  100. V. M. Bhopale, G. Smith, H. E. Jordan, and G. A. Schad, “Developmental biology and migration of Strongyloides ratti in the rat,” Journal of Parasitology, vol. 78, no. 5, pp. 861–868, 1992. View at Publisher · View at Google Scholar · View at Scopus
  101. M. Mojon, C. Saura, N. Roojee, and R. T. M. Sung, “An experimental model for therapeutic trials of anthelminthic drugs,” Journal of Antimicrobial Chemotherapy, vol. 19, no. 1, pp. 73–77, 1987. View at Publisher · View at Google Scholar · View at Scopus
  102. C. E. Olson and E. L. Schiller, “Strongyloides ratti infections in rats. II. Effects of cortisone treatment,” American Journal of Tropical Medicine and Hygiene, vol. 27, no. 3, pp. 527–531, 1978. View at Google Scholar · View at Scopus
  103. R. E. Weesner, J. Kolinjivadi, R. A. Giannella, T. Huitger-O'Connor, and R. M. Genta, “Effect of Strongyloides ratti on small bowel function in normal and immunosuppressed host rats,” Digestive Diseases and Sciences, vol. 33, no. 10, pp. 1316–1321, 1988. View at Publisher · View at Google Scholar · View at Scopus
  104. V. L. T. Mati, P. Raso, and A. L. de Melo, “Strongyloides stercoralis infection in marmosets: replication of complicated and uncomplicated human disease and parasite biology,” Parasites & Vectors, vol. 7, no. 1, article 579, 2014. View at Publisher · View at Google Scholar
  105. P. Steinmann, X.-N. Zhou, Z.-W. Du et al., “Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial,” PLoS Neglected Tropical Diseases, vol. 2, no. 10, article no. e322, 2008. View at Publisher · View at Google Scholar · View at Scopus