Comparison of the Accuracy of Four Malaria Diagnostic Methods in a High Transmission Setting in Coastal Cameroon

Table 3

Diagnostic sensitivity, specificity, PPV, NPV, and ROC analysis, and kappa values of agreement between test methods.

		Axillary temp; (>37.5°C)	Light microscopy	SD Bioline™
Sensitivity	%	74.3	94.86	95.33
	(number/total)	159/214	203/214	204/214
	95%CI	67.90-80.01	90.99-97.41	91.57-97.74
Specificity	%	53.77	94.34	94.34
	(number/total)	57/106	100/106	100/106
	95%CI	43.82-63.51	88.09-97.86	88.09-97.89
NPV	%	50.89	90.09	90.91
	(number/total)	57/112	100/111	100/110
	95%CI	43.72-58.03	83.61-94.18	84.50-94.83
PPV	%	76.44	97.13	97.14
	(number/total)	159/208	203/209	204/210
	95%CI	72.26-80.17	93.96-98.66	93.98-98.67
ROC analysis	AUC	0.640	0.946	0.948
	Standard error	0.032	0.012	0.012
	95%CI	0.585-0.693	0.915-0.968	0.918-0.970
Kappa values		0.277	0.882	0.888

Legend. PPV: positive predictive value, NPV: negative predictive value, ROC: receiver operating characteristic curve, AUC: area under the ROC curve, RDT: rapid diagnostic test, and 95CI: 95% confidence interval. Nested PCR considered reference method.