Histopathological, Immunohistochemical and Biochemical Studies of Murine Hepatosplenic Tissues Affected by Chronic Toxoplasmosis

Figure 9

Photomicrographs of liver tissue (top row) and spleen (bottom row). The normal non-infected group showed (a) normal liver tissue (negative staining). The infected group showed (b) moderate inflammation and mild intensity, (c) mild inflammation and moderate positivity, (d) mild intensity and marked inflammation, (e) moderate positivity and marked inflammation, and (f) marked inflammation and strong positivity. Prominent cytoplasmic immune reactivity in the splenic cells of the white and red pulps is obvious. Because of cellular proliferation, the white pulp grew in size. The distinction between white and red pulp is significantly obscured. Dark pigmentation of most cells, while the spaces between sinusoids noticed markedly enlarged. The observed disarray may be caused by splenic lymphoid tissue hyperplasia. Inflammatory infiltration is evident in all sections of the infected group (caspase 3, ×100).

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