Immunity to Protozoan Parasites
1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil
2Departamento de Biologia Celular Molecular e Bioagentes Patogenicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
3Laboratorio de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Católica de Córdoba, X5004ASK Cordoba, Argentina
4CINTERGEN, Escola Paulista de Medicina, UNIFESP, 04044-010 São Paulo, SP, Brazil
Immunity to Protozoan Parasites
Description
Protozoan parasites cause several diseases, such as malaria, leishmaniasis, and trypanosomiasis, which hamper human development worldwide. Parasitic infections by either extra- or intracellular protozoans often follow chronic courses, owing to coevolution between parasites and host immune system. The survival of pathogenic parasites depends on their ability to elicit and, at the same time, to evade host's innate and adaptive immune responses. A great challenge in immunology and parasitology is the development of strategies that favor immunity against protozoan parasites and prevent their evasion, long-term survival, and transmission.
We invite investigators to contribute with original research articles as well as reviews that improve our understanding on immunity to protozoan parasites, both in humans and experimental models, helping development of effective vaccines and immunotherapeutic tools to treat patients. Potential topics include, but are not limited to:
- Mechanisms of innate and adaptive immunity to protozoan parasites
- New cellular and animal models to study immunity to protozoan parasites
- The role of new T-cell subsets and cytokines in protozoan infections
- Transcriptional control of immune responses to protozoan parasites
- Protozoan strategies to subvert and modulate host immune responses
- TLR/NLR agonists useful as vaccine adjuvants
- Development of new vaccines and target protozoan antigens
- Development of novel immunotherapeutic tools against protozoan infections
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