A Statistical Variance Components Framework for Mapping Imprinted Quantitative Trait Locus in Experimental Crosses
Table 3
The power, MLEs, and REMLs of the QTL position, and effect parameters estimated based on 100
simulation replicates for a QTL showing different imprinting effects under the
sampling
design. The square roots of the mean squared errors of the parameters are given
in parentheses.
Estimation
Position
method
48 cm
10
8
6
0.5
0.5
2
Pow
Pow
ipower
3
0
ML
48.98
10.06
8.02
5.94
2.94
0.10
0.65
0.25
2.04
0.98
0.99
0.91
(7.36)
(0.716)
(0.388)
(0.722)
(1.197)
(0.217)
(0.694)
(0.426)
(0.207)
REML
48.54
9.96
7.95
5.90
2.95
0.09
0.64
0.57
1.97
0.97
0.99
0.86
(9.62)
(0.705)
(0.428)
(0.747)
(1.501)
(0.180)
(0.598)
(0.609)
(0.226)
0
3
ML
46.62
10.05
8.02
6.08
0.09
2.76
0.69
0.30
2.05
0.97
1.00
0.89
(8.11)
(0.680)
(0.442)
(0.584)
(0.201)
(1.052)
(0.722)
(0.430)
(0.193)
REML
48.7
10.04
7.98
5.91
0.09
2.95
0.61
0.57
1.98
0.96
0.98
0.88
(7.40)
(0.560)
(0.506)
(0.615)
(0.195)
(1.279)
(0.663)
(0.544)
(0.225)
1
2
ML
47.8
10.09
8.00
6.11
0.84
2.04
0.66
0.32
2.02
0.97
1.00
0.24
(7.83)
(0.634)
(0.468)
(0.666)
(0.615)
(0.994)
(0.811)
(0.475)
(0.203)
REML
49.66
10.02
7.96
5.90
1.08
1.73
0.68
0.61
2.00
0.97
0.99
0.09
(11.06)
(0.606)
(0.548)
(0.668)
(0.679)
(0.958)
(0.707)
(0.616)
(0.216)
Po and Po correspond to the overall QTL effect test (2.27)
calculated using the empirical and theoretical cutoffs, respectively; ipower
refers to the imprinting test power corresponding to test (2.29). See Table 2 for
explanations of other parameters.
