Journal of Probability and Statistics / 2012 / Article / Tab 8

Research Article

The Transmission Disequilibrium/Heterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases

Table 8

Powers of RC-TDT and RC-TDH in simulation study 1.

Model
RC-TDT RC-TDH RC-TDT RC-TDH RC-TDT RC-TDH

0.130.870.680.970.991.00
0.080.410.610.730.970.98
0.100.430.650.770.970.97
0.090.160.560.590.980.96
0.210.860.991.001.001.00
0.150.400.980.991.001.00

(dominant), (recessive), (additive); : 1 (1.0), 2 (0.5); with type-I error rate .05 based on 500 independent replicates of 150 nuclear families. is the measurement for linkage disequilibrium. When , there is no linkage disequilibrium. In this simulation study, all the parental marker genotypes are missing.

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