The Transmission Disequilibrium/Heterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases

Table 8

Powers of RC-TDT and RC-TDH in simulation study 1.

Model	Δ=0.1		Δ=0.5		Δ=0.9
	RC-TDT	RC-TDH	RC-TDT	RC-TDH	RC-TDT	RC-TDH
𝐷1	0.13	0.87	0.68	0.97	0.99	1.00
𝐷2	0.08	0.41	0.61	0.73	0.97	0.98
𝐴1	0.10	0.43	0.65	0.77	0.97	0.97
𝐴2	0.09	0.16	0.56	0.59	0.98	0.96
𝑅1	0.21	0.86	0.99	1.00	1.00	1.00
𝑅2	0.15	0.40	0.98	0.99	1.00	1.00

𝐷 (dominant), 𝑅 (recessive), 𝐴 (additive); 𝑓_𝐷𝐷: 1 (1.0), 2 (0.5); with type-I error rate .05 based on 500 independent replicates of 150 nuclear families. Δ is the measurement for linkage disequilibrium. When Δ=0, there is no linkage disequilibrium. In this simulation study, all the parental marker genotypes are missing.