Journal of Probability and Statistics / 2012 / Article / Tab 9

Research Article

The Transmission Disequilibrium/Heterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases

Table 9

Powers of the RC-TDT and RC-TDH in simulation study 2.

Scenario Dominant Recessive AdditiveMultiplicative
RC-TDT RC-TDH RC-TDT RC-TDH RC-TDT RC-TDH RC-TDT RC-TDH

0.00.000.650.000.370.000.190.000.13
0.20.100.820.020.530.030.350.010.25
S10.40.570.960.370.850.330.720.250.63
0.60.981.000.861.000.870.980.780.94
0.81.001.001.001.001.001.000.991.00
1.01.001.001.001.001.001.001.001.00

S50.00.000.170.000.040.000.010.000.01
0.20.020.270.000.090.010.100.000.06
0.40.250.620.040.290.160.430.060.24
0.60.790.930.220.530.650.810.400.62
0.80.991.000.610.890.960.990.810.94
1.01.001.000.890.991.001.000.970.99

In this simulation, we used 50% families with available parental marker genotypes and 50% families without parental marker genotypes.

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