Escalation with Overdose Control Using Ordinal Toxicity Grades for Cancer Phase I Clinical Trials

Figure 6

Dose-toxicity relationship under the proportional (EWOC-POM) and nonproportional odds models (M₁ and M₂) when the true MTD 𝛾=0.1. The dashed horizontal line corresponds to the target probability of DLT 𝜃=0.33.