Research Article

Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease

Table 4

Descriptive statistics of the first-degree relatives of COHORT proband subjects stratified by relationship.

Relationship
Parents Siblings Children Total

Not affected Number 739 1110 931 2780
Ave age 70 50 26 42
Min age 27 0 0 18
Max age 111 93 62 88
sd 13 15 14 13
% 26.6 39.9 33.5

Affected Number 379 237 13 629
Ave age 45 42 36 45
Min age 18 7 23 11
Max age 82 70 44 82
sd 11 11 7 12
% 60.3 37.7 2.1

Total Number 1118 1347 944 3409