Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease

Table 6

Conditional survival probabilities estimated from the COHORT combined data.

CAG	45 years	50 years	55 years	60 years	65 years	70 years
36	0.01 (0.00, 0.02)	0.02 (0.00, 0.04)	0.04 (0.00, 0.08)	0.07 (0.01, 0.13)	0.11 (0.20, 0.20)	0.17 (0.07, 0.28)
37	0.01 (0.00, 0.02)	0.03 (0.01, 0.06)	0.06 (0.02, 0.11)	0.11 (0.05, 0.18)	0.18 (0.27, 0.27)	0.28 (0.17, 0.39)
38	0.02 (0.01, 0.03)	0.05 (0.02, 0.08)	0.10 (0.06, 0.15)	0.18 (0.12, 0.25)	0.29 (0.38, 0.38)	0.43 (0.33, 0.53)
39	0.03 (0.02, 0.04)	0.08 (0.05, 0.11)	0.17 (0.12, 0.21)	0.29 (0.23, 0.35)	0.44 (0.52, 0.52)	0.60 (0.52, 0.69)
40	0.05 (0.04, 0.06)	0.14 (0.11, 0.16)	0.27 (0.23, 0.31)	0.44 (0.39, 0.50)	0.62 (0.68, 0.68)	0.77 (0.72, 0.82)
41	0.08 (0.07, 0.09)	0.22 (0.19, 0.24)	0.41 (0.37, 0.44)	0.61 (0.57, 0.65)	0.78 (0.81, 0.81)	0.88 (0.86, 0.91)
42	0.13 (0.12, 0.14)	0.34 (0.32, 0.36)	0.57 (0.54, 0.60)	0.77 (0.74, 0.79)	0.89 (0.90, 0.90)	0.95 (0.94, 0.96)
43	0.21 (0.20, 0.22)	0.48 (0.46, 0.51)	0.72 (0.70, 0.75)	0.87 (0.86, 0.89)	0.95 (0.95, 0.95)	0.98 (0.97, 0.98)
44	0.31 (0.29, 0.33)	0.63 (0.60, 0.65)	0.83 (0.81, 0.85)	0.93 (0.92, 0.95)	0.97 (0.98, 0.98)	0.99 (0.99, 0.99)
45	0.43 (0.40, 0.45)	0.74 (0.72, 0.77)	0.90 (0.88, 0.92)	0.96 (0.96, 0.97)	0.99 (0.99, 0.99)	>0.99 (0.99, >0.99)
46	0.53 (0.50, 0.56)	0.82 (0.80, 0.85)	0.94 (0.93, 0.95)	0.98 (0.97, 0.99)	0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
47	0.61 (0.57, 0.64)	0.87 (0.85, 0.89)	0.96 (0.95, 0.97)	0.99 (0.98, 0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
48	0.66 (0.63, 0.70)	0.90 (0.88, 0.92)	0.97 (0.96, 0.98)	0.99 (0.99, >0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
49	0.70 (0.66, 0.74)	0.92 (0.90, 0.94)	0.98 (0.97, 0.99)	0.99 (0.99, >0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
50	0.73 (0.68, 0.77)	0.93 (0.91, 0.95)	0.98 (0.97, 0.99)	>0.99 (0.99, >0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
51	0.74 (0.69, 0.80)	0.94 (0.91, 0.96)	0.98 (0.98, 0.99)	>0.99 (0.99, >0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
52	0.76 (0.70, 0.82)	0.94 (0.91, 0.97)	0.99 (0.98, >0.99)	>0.99 (0.99, >0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
53	0.77 (0.70, 0.83)	0.95 (0.92, 0.98)	0.99 (0.98, >0.99)	>0.99 (0.99, >0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
54	0.77 (0.70, 0.85)	0.95 (0.92, 0.98)	0.99 (0.98, >0.99)	>0.99 (0.99, >0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
55	0.78 (0.70, 0.86)	0.95 (0.92, 0.99)	0.99 (0.98, >0.99)	>0.99 (0.99, >0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)
56	0.78 (0.70, 0.87)	0.95 (0.92, 0.99)	0.99 (0.98, >0.99)	>0.99 (0.99, >0.99)	>0.99 (>0.99, >0.99)	>0.99 (>0.99, >0.99)