Number of Patients per Cohort and Sample Size Considerations Using Dose Escalation with Overdose Control

Table 7

Average posterior standard deviation and average length of HPD of the posterior distribution of the MTD that are achieved for a given sample size for 𝜃=0.3.

𝑛	Mean SD	Length of 90% HPD	Length of 95% HPD
6	0.2453	0.7386	0.8161
8	0.2399	0.7238	0.8040
10	0.2351	0.7111	0.7925
12	0.2309	0.6985	0.7818
14	0.2281	0.6913	0.7755
16	0.2248	0.6821	0.7678
18	0.2221	0.6748	0.7608
20	0.2197	0.6673	0.7546
22	0.2176	0.6624	0.7500
24	0.2153	0.6557	0.7439
26	0.2136	0.6505	0.7395
28	0.2119	0.6455	0.7352
30	0.2102	0.6410	0.7313
32	0.2085	0.6350	0.7257
34	0.2072	0.6313	0.7221
36	0.2057	0.6262	0.7176
38	0.2050	0.6240	0.7162
40	0.2036	0.6200	0.7123