Table of Contents
Journal of Powder Technology
Volume 2013 (2013), Article ID 108569, 9 pages
http://dx.doi.org/10.1155/2013/108569
Research Article

Self-Nanoemulsifying Powder of Isotretinoin: Preparation and Characterization

1Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Mehsana, Gujarat 384 001, India
2Department of Clinical Pharmacy, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Mehsana, Gujarat 384 001, India
3Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Mehsana, Gujarat 384 001, India

Received 8 May 2013; Revised 7 August 2013; Accepted 25 September 2013

Academic Editor: Jürgen Tomas

Copyright © 2013 Hitesh Chavda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the present investigation an attempt was made to enhance the solubility and dissolution of poorly soluble drug, isotretinoin, by formulating self-nanoemulsifying drug delivery system (SNEDDS). Liquid SNEDDSs were prepared using Transcutol P as oil, Tween 80 as surfactant, and PEG 400 as cosurfactant. Pseudoternary phase diagrams were constructed to identify the efficient self-nanoemulsification region. The formulation with 40% oil (Transcutol P) and 60% surfactant: cosurfactant (Tween 80: PEG 400) ratio of 1 : 1 was optimized based on evaluation parameters for droplet size analysis, self-emulsification capacity, zeta potential, and in vitro drug release performance. The optimized system contains mean droplet size of 36.60 nm and zeta potential (ζ) −26.73 mV. The optimized formulation A1 was adsorbed onto Fujicalin to produce solid SNEDDS, which exhibited good flow properties and preserved the self-emulsification properties of liquid SNEDDS. The differential scanning calorimetry, FT-IR studies of solid SNEDDS revealed transformation of isotretinoin into molecularly dissolved state in the liquid SNEDDS. In vitro dissolution profiles showed that dissolution rate of ISN from solid SNEDDS was significantly greater as compared to pure drug.