A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in a Group of 1-Aryl-5-(1-H-pyrrol-1-yl)-1-H-pyrazole-3-carboxamides

Table 5

Beta coefficients and t-test for significance of coefficients in (11).

	Beta	𝑡 (10)	𝑃-level
𝑆^𝐸5 (HOMO − 2)*	0.28	3.90	<0.004
𝑄8^max	−0.74	−11.05	<0.000002
𝐹19 (HOMO − 2)*	−0.38	−5.75	<0.0003
ΦR1	−0.29	−4.52	<0.001