Table of Contents
Journal of Radiotherapy
Volume 2014 (2014), Article ID 268340, 8 pages
http://dx.doi.org/10.1155/2014/268340
Clinical Study

Late Toxicities after Conventional Radiotherapy for Nasopharyngeal Carcinoma: Incidence and Risk Factors

1Department of Radiation Oncology, Habib Bourguiba University Hospital, Majida Boulila Road 3029, Sfax 3029, Tunisia
2Department of Otolaryngology, Habib Bourguiba University Hospital, Sfax 3029, Tunisia
3Department of Radiology, Habib Bourguiba University Hospital, Sfax 3029, Tunisia
4Department of Medical Oncology, Habib Bourguiba University Hospital, Sfax 3029, Tunisia

Received 30 September 2013; Revised 30 November 2013; Accepted 29 December 2013; Published 10 February 2014

Academic Editor: Wai Tong Ng

Copyright © 2014 Wicem Siala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Daoud, N. Toumi, W. Siala, A. Ghorbel, M. M. Drira, and M. Frikha, “Results of a prospective randomised trial comparing conventional radiotherapy to split course bifractionated radiation therapy in patients with nasopharyngeal carcinoma,” Radiotherapy and Oncology, vol. 85, no. 1, pp. 17–23, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. R. J. Bensadoun, F. Eschwège, G. Schwaab, and P. Wibault, “Complications tardives et séquelles de la radiothérapie des carcinomes du nasopharynx chez l’adulte. A propos de 79 patients traités à l’institut Gustave-Roussy entre 1970 et 1978,” Bulletin du Cancer. Radiothérapie, vol. 78, pp. 149–164, 1991. View at Google Scholar
  3. A. W. M. Lee, W. T. Ng, W. M. Hung et al., “Major late toxicities after conformal radiotherapy for nasopharyngeal carcinoma patient and treatment related risk factors,” International Journal of Radiation Oncology Biology Physics, vol. 73, no. 4, pp. 1121–1128, 2009. View at Publisher · View at Google Scholar
  4. S.-A. Yeh, Y. Tang, C.-C. Lui, Y.-J. Huang, and E.-Y. Huang, “Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone,” International Journal of Radiation Oncology Biology Physics, vol. 62, no. 3, pp. 672–679, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Bonfils, N. Preobrajenski, A. Florent, and J. L. Bensimon, “Sténose choanale post radique: une complication rare de la radiothérapie des carcinomes nasopharyngés,” Cancer Radiothérapie, vol. 11, pp. 143–145, 2007. View at Google Scholar
  6. J. Daoud, H. Ben Salah, W. Kammoun et al., “Radio-induced glioblastoma and myxoma after treatment of indifferenciated carcinoma of the nasopharynx,” Cancer/Radiotherapie, vol. 4, no. 6, pp. 469–472, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Daoud, F. Elloumi, I. Maaloul et al., “Erysipela after treatment of nasopharyngeal carcinoma,” Cancer/Radiotherapie, vol. 9, no. 8, pp. 587–589, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Daoud, W. Siala, F. Guermazi et al., “Hypothyroidism following cervical irradiation in the management of carcinoma of the nasopharynx and of the breast: a prospective study on eighty-four cases,” Cancer/Radiotherapie, vol. 9, no. 3, pp. 140–147, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. H. B. Honoré, S. M. Bentzen, K. Møller, and C. Grau, “Sensori-neural hearing loss after radiotherapy for nasopharyngeal carcinoma: individualized risk estimation,” Radiotherapy and Oncology, vol. 65, no. 1, pp. 9–16, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. X.-M. Huang, Y.-Q. Zheng, X.-M. Zhang et al., “Diagnosis and management of skull base osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma,” The Laryngoscope, vol. 116, no. 9, pp. 1626–1631, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Nasr Ben Ammar, N. Chaari, L. Kochbati et al., “Radionécrose cérébrale chez les patients irradiés pour cancer du nasopharynx: à propos de neuf cas,” Cancer/Radiothérapie, vol. 11, pp. 234–240, 2007. View at Google Scholar
  12. J. J. Mazeron and L. Grimard, “Effets tardifs des radiations ionisantes sur les tissus de la sphère otorhinolaryngologique,” Cancer Radiothérapie, vol. 1, pp. 692–705, 1997. View at Google Scholar
  13. K. Bjordal, S. Kaasa, and A. Mastekaasa, “Quality of life in patients treated for head and neck cancer: a follow-up study 7 to 11 years after radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 28, no. 4, pp. 847–856, 1994. View at Google Scholar · View at Scopus
  14. D. M. Brizel, T. H. Wasserman, M. Henke et al., “Phase III randomized trial of amifostine as a radioprotector in head and neck cancer,” Journal of Clinical Oncology, vol. 18, no. 19, pp. 3339–3345, 2000. View at Google Scholar · View at Scopus
  15. J. Buentzel, O. Micke, I. A. Adamietz, A. Monnier, M. Glatzel, and A. de Vries, “Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study,” International Journal of Radiation Oncology Biology Physics, vol. 64, no. 3, pp. 684–691, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. A. D. Sasse, L. G. de Oliveira Clark, E. C. Sasse, and O. A. C. Clark, “Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis,” International Journal of Radiation Oncology Biology Physics, vol. 64, no. 3, pp. 784–791, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas, “Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer,” International Journal of Radiation Oncology Biology Physics, vol. 52, no. 3, pp. 739–747, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. F. R. Burlage, J. M. Roesink, H. H. Kampinga et al., “Protection of salivary function by concomitant pilocarpine during radiotherapy: a double-blind, randomized, placebo-controlled study,” International Journal of Radiation Oncology Biology Physics, vol. 70, no. 1, pp. 14–22, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Deutsch, “The use of pilocarpine hydrochloride to prevent xerostomia in a child treated with high dose radiotherapy for nasopharynx carcinoma,” Oral Oncology, vol. 34, no. 5, pp. 381–382, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. M. W. Münter, C. P. Karger, S. G. Hoffner et al., “Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy,” International Journal of Radiation Oncology Biology Physics, vol. 58, no. 1, pp. 175–184, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Astreinidou, J. M. Roesink, C. P. J. Raaijmakers et al., “3D MR sialography as a tool to investigate radiation-induced xerostomia: feasibility study,” International Journal of Radiation Oncology Biology Physics, vol. 68, no. 5, pp. 1310–1319, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Dirix, F. de Keyzer, V. Vandecaveye, S. Stroobants, R. Hermans, and S. Nuyts, “Diffusion-weighted magnetic resonance imaging to evaluate major salivary gland function before and after radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 71, no. 5, pp. 1365–1371, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. M. W. Münter, S. Hoffner, H. Hof et al., “Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without amifostine,” International Journal of Radiation Oncology Biology Physics, vol. 67, no. 3, pp. 651–659, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Eisbruch, H. M. Kim, J. E. Terrell, L. H. Marsh, L. A. Dawson, and J. A. Ship, “Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer,” International Journal of Radiation Oncology Biology Physics, vol. 50, no. 3, pp. 695–704, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Maes, C. Weltens, P. Flamen et al., “Preservation of parotid function with uncomplicated conformal radiotherapy,” Radiotherapy and Oncology, vol. 63, no. 2, pp. 203–211, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Li, J. M. G. Taylor, R. K. Ten Haken, and A. Eisbruch, “The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy,” International Journal of Radiation Oncology Biology Physics, vol. 67, no. 3, pp. 660–669, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. E. H. N. Pow, D. L. W. Kwong, A. S. McMillan et al., “Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial,” International Journal of Radiation Oncology Biology Physics, vol. 66, no. 4, pp. 981–991, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Y. Lee, F. F. de Arruda, D. R. Puri et al., “A comparison of intensity-modulated radiation therapy and concomitant boost radiotherapy in the setting of concurrent chemotherapy for locally advanced oropharyngeal carcinoma,” International Journal of Radiation Oncology Biology Physics, vol. 66, no. 4, pp. 966–974, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. M. B. Parliament, R. A. Scrimger, S. G. Anderson et al., “Preservation of oral health-related quality of life and salivary flow rates after inverse-planned intensity- modulated radiotherapy (IMRT) for head-and-neck cancer,” International Journal of Radiation Oncology Biology Physics, vol. 58, no. 3, pp. 663–673, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Toledano, P. Garaud, D. Serin et al., “Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conservative surgery enhances late toxicities,” Cancer/Radiotherapie, vol. 10, no. 4, pp. 158–167, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. P. M. L. Teo, S. F. Leung, A. T. C. Chan et al., “Final report of a randomized trial on altered-fractionated radiotherapy in nasopharyngeal carcinoma prematurely terminated by significant increase in neurologic complications,” International Journal of Radiation Oncology Biology Physics, vol. 48, no. 5, pp. 1311–1322, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. H. J. Keene and T. J. Fleming, “Prevalence of caries-associated microflora after radiotherapy in patients with cancer of the head and neck,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 64, no. 4, pp. 421–426, 1987. View at Google Scholar · View at Scopus
  33. A. M. Kielbassa, W. Hinkelbein, E. Hellwig, and H. Meyer-Lückel, “Radiation-related damage to dentition,” Lancet Oncology, vol. 7, no. 4, pp. 326–335, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. C. G. Murray, J. Herson, T. E. Daly, and S. Zimmerman, “Radiation necrosis of the mandible: a 10 year study. Part II. Dental factors; onset, duration and management of necrosis,” International Journal of Radiation Oncology Biology Physics, vol. 6, no. 5, pp. 549–553, 1980. View at Google Scholar · View at Scopus
  35. S. Wei, “Clinical use of fluoride: a state of the art conférence on the uses of floride in clinical chemesty,” The Journal of the American Dental Association, vol. 109, p. 472, 1984. View at Google Scholar
  36. P. J. Hancock, J. B. Epstein, and G. R. Sadler, “Oral and dental management related to radiation therapy for head and neck cancer,” Journal of the Canadian Dental Association, vol. 69, no. 9, pp. 585–590, 2003. View at Google Scholar · View at Scopus
  37. V. Rudat, J. Meyer, F. Momm et al., “Protective effect of amifostine on dental health after radiotherapy of the head and neck,” International Journal of Radiation Oncology Biology Physics, vol. 48, no. 5, pp. 1339–1343, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Raoul, J. M. Maes, D. Pasquier, J. Nicola, and J. Ferri, “Ostéoradionecrose des maxillaires,” EMC-Stomatologie, vol. 1, pp. 255–276, 2005. View at Google Scholar
  39. A.-G. Chaux-Bodard, R. Gourmet, X. Montbarbon, S. Bodard, and P. Breton, “Postradiation dental extractions,” Revue de Stomatologie et de Chirurgie Maxillo-Faciale, vol. 105, no. 5, pp. 269–273, 2004. View at Google Scholar · View at Scopus
  40. A. C. Tong, A. C. Leung, J. C. Cheng, and J. Sham, “Incidence of complicated healing and ostéoradionécroses following tooth extraction in patients receiving radiotherapy for treatment of nasopharyngeal carcinoma,” Australian Dental Journal, vol. 44, pp. 187–194, 1999. View at Google Scholar
  41. J. M. Bedwinek, L. J. Shukovsky, G. H. Fletcher, and T. E. Daley, “Osteonecrosis in patients treated with definitive radiotherapy for squamous cell carcinomas of the oral cavity and naso and oropharynx,” Radiology, vol. 119, no. 3, pp. 665–667, 1976. View at Google Scholar · View at Scopus
  42. M.-C. Cheung, A. S. Chan, S. C. Law, J. H. Chan, and V. K. Tse, “Impact of radionecrosis on cognitive dysfunction in patients after radiotherapy for nasopharyngeal carcinoma,” Cancer, vol. 97, no. 8, pp. 2019–2026, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. R. E. Marx, “Osteoradionecrosis: a new concept of its pathophysiology,” Journal of Oral and Maxillofacial Surgery, vol. 41, no. 5, pp. 283–288, 1983. View at Google Scholar · View at Scopus
  44. D. H. Koga, J. V. Salvajoli, L. P. Kowalski, I. N. Nishimoto, and F. A. Alves, “Dental extractions related to head and neck radiotherapy: ten-year experience of a single institution,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 105, no. 5, pp. e1–e6, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. K.-P. Chang, N.-M. Tsang, C.-Y. Chen, J.-L. Su, and S.-P. Hao, “Endoscopic management of skull base osteoradionecrosis,” The Laryngoscope, vol. 110, no. 7, pp. 1162–1165, 2000. View at Google Scholar · View at Scopus
  46. Y.-M. Jen, W.-L. Hsu, C.-Y. Chen et al., “Different risks of symptomatic brain necrosis in NPC patients treated with different altered fractionated radiotherapy techniques,” International Journal of Radiation Oncology Biology Physics, vol. 51, no. 2, pp. 344–348, 2001. View at Publisher · View at Google Scholar · View at Scopus
  47. A. W. M. Lee, D. L. W. Kwong, S. F. Leung et al., “Factors affecting risk of symptomatic temporal necrosis: significance of fractional dose and treatment time,” International Journal of Radiation Oncology Biology Physics, vol. 53, pp. 75–85, 2002. View at Google Scholar
  48. D. L. W. Kwong, W. I. Wei, J. S. T. Sham et al., “Sensorineural hearing loss in patients treated for nasopharyngeal carcinoma: a prospective study of the effect of radiation and cisplatin treatment,” International Journal of Radiation Oncology Biology Physics, vol. 36, no. 2, pp. 281–289, 1996. View at Publisher · View at Google Scholar · View at Scopus
  49. C. Grau, K. Moller, M. Overgaard, J. Overgaard, and O. Elbrond, “Sensori-neural hearing loss in patients treated with irradiation for nasopharyngeal carcinoma,” International Journal of Radiation Oncology Biology Physics, vol. 21, no. 3, pp. 723–728, 1991. View at Google Scholar · View at Scopus