Repeat Whole Brain Radiation Therapy with a Simultaneous Infield Boost: A Novel Technique for Reirradiation

Table 4

Literature summary.

	Shehata et al. [6]	Kurup et al. [7]	Hazuka and Kinzie [8]	Cooper et al. [9]	Wong et al. [10]	Abdel-Wahab et al. [12]	Sadikov et al. [11]	Son et al. [13]	Present study
Number of patients	35	56	44	52	86	15	72	17	16
Initial RT fractionation; (dose Gy/num frac)	35/10; 30/10	18/3; 20/5; 30/10	30/10	30/10	30/10	35/10	20/5	35/14	35/14
Repeat WBRT fractionation; (dose Gy/num frac)	10/1	20/10	25/8	25/10	20/10	30/20 BID; (partial brain)	25/10	21.6/12	20/10 WB; 30/10 SIB boost
Time between initial and repeat WBRT; (months)	NR	6.3	7.8	>4	7.6	10	9.6	15	11.3
Response
Improved	68%	75%	27%	42%	70%	60%	40%	80%	46%
Stable	25%	12.5%	41%	52%	29%	27%	33%	20%	40%
Survival (months)	NR	3.5	2	4	4	3.2	4.1	5.2	2.7
Percentage of patients with solitary lesion at the time of repeat WBRT	NR	NR	NR	NR	45%	NR	14%	NR	0%

NR: not reported, WBRT: whole brain radiation therapy, Gy: gray, Num: number, and Frac: fractions.
Table is adapted from that presented by Sadikov et al. and Son et al. [11, 13].