Stereotactic Hypofractionated Irradiation for Metastatic, Inoperable, and Recurrent Malignancies: A Modern Necessity, rather than a Luxury

Susheela, Sridhar P.; Revannasiddaiah, Swaroop; Basavalingaiah, Ajaikumar

doi:https://doi.org/10.1155/2014/489824

Journal of Radiotherapy

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Review Article | Open Access

Volume 2014 | Article ID 489824 | https://doi.org/10.1155/2014/489824

Stereotactic Hypofractionated Irradiation for Metastatic, Inoperable, and Recurrent Malignancies: A Modern Necessity, rather than a Luxury

Sridhar P. Susheela,¹Swaroop Revannasiddaiah,¹and Ajaikumar Basavalingaiah¹

Academic Editor: Oliver Micke

Received28 Sept 2014

Revised06 Dec 2014

Accepted09 Dec 2014

Published28 Dec 2014

Abstract

Stereotactic-irradiation combines highly conformal delivery of radiation to selected volumes at large doses per fraction, with the treatment completed typically within one to five fractions. The radiobiological equivalence of doses delivered by stereotactic-irradiation (often beyond 80–100 Gy) is much higher in comparison to the doses achievable by conventional fractionation. At the high fraction sizes used in stereotactic-irradiation, evidence suggests the role of various radiobiological mechanisms of actions, which are not traditionally relatable with conventional radiotherapy. In spite of the accumulating evidence in favour of the efficacy of stereotactic irradiation in terms of improving local control and at times attaining increments in survival, the clinical adoption of the technique remains dismal. This review provides a brief description of the available evidence describing the benefits of stereotactic-irradiation for the management of patients with oligometastases, unresectable malignancies and for disease recurrence after prior radiotherapy. Given the growing body of evidence illustrating the efficacy of stereotactic irradiation among patients with conditions which were previously often regarded as untreatable, it is likely that the widespread adoption of stereotactic irradiation may achieve cure in a few patients, while in the remainder providing prospects of long term local control. This could be a step in the direction of converting incurable malignancies into chronic controllable diseases.

1. Introduction

In the history of humanity’s war against disease, there have been many instances wherein otherwise fatal diseases have been tactfully converted into chronic controllable conditions. As examples, while diabetes and hypertension remain largely incurable to this date, modern medicine has allowed countless persons with these diseases to lead nearly normal lives.

The field of oncology has seen its own share of successes; many situations which were uniformly fatal in the past, are now regarded as “treatable,” even if not always “curable.” An excellent example would be the case of metastatic receptor-positive breast cancer, where patients with multiple metastases are expected to survive for long periods with the optimized use of targeted therapy, hormone therapy, and focal irradiation.

The recent emergence of various technological innovations with regard to image guidance and precision radiotherapy has allowed the routine use of hypofractionated stereotactic radiotherapy in extracranial sites. This technique of “stereotactic body radiotherapy” (SBRT), also referred to by other acronyms, SABR (stereotactic ablative RT) and ESRT (extracranial stereotactic RT), happens to utilize high doses of radiation delivered in a single or a limited number of fractions (typically less than five) with very high conformality to the target area. Such an approach is bestowed with a very high therapeutic ratio, given that the biological effectiveness of doses deposited on the target tissue is very high (often beyond 100 Gray), while the doses to normal tissues are restricted to a minimum [1–3].

Despite the growing evidence in the favour of SABR for various indications, it remains clinically underutilized largely due to a lack of awareness of the potential that this new and emerging treatment modality holds. This review highlights the capabilities of SABR in treating conditions which could otherwise be undertreated or, even worse, be met with neglect.

2. The Meaning of Stereotactic Ablative Radiotherapy (SABR)

The use of fractionated radiotherapy (RT) utilizing doses in the order of 2 Gray (Gy) per fraction (conventional fractionation) has dominated the field of external beam RT for nearly a century. It must be remembered that conventional fractionation was evolved out of radiobiological concepts in an era where the X-ray energies were limited mostly to the kilovoltage range (having a poor penetrating power). In the absence of technology to focus the radiation upon the target volume with precision, the focus was mainly upon the enhancement of therapeutic ratio, which meant to optimize the effect upon the target, while limiting toxic effects upon normal tissues to a minimum [4–7].

In the recent decades, technological breakthroughs such as improvements in sectional imaging, intensity-modulation for conformal RT, and linear accelerators with the ability to perform high-precision RT have allowed the oncologist to experiment with hypofractionation, using higher-doses per fraction, typically completing treatment in a shorter period of time. The feasibility of extrapolation of the principles of stereotactic intracranial radiosurgery (which has been in utility for decades) onto extracranial sites had been demonstrated decades ago with conventional linear accelerators. This has been often referred to by various synonyms, such as “stereotactic body radiotherapy (SBRT),” extracranial stereotactic radiotherapy (ESRT), and sterotactic ablative radiosurgery (SABR). Of all the currently used nomenclatures, the term “SABR” (stereotactic ablative radiosurgery) hints at the technique’s peculiar radiobiological ablative action [8–11].

SABR typically is delivered in a maximum of five fractions, with dose per fraction ranging from 5 Gy to 30 Gy, depending upon the size and relative location of the target in relation to nearby critical structures. Additionally, the recent availability of image-guidance has conferred a reasonable degree of safety and reliability in the delivery of frameless SABR.

Experiments have demonstrated radiobiological differences between conventionally fractionated RT and SABR. While the radiobiological basis of conventionally fractionated RT is often discussed in terms of the 4Rs of radiobiology (reoxygenation of tumour cells, repopulation of normal tissues, reassortment of tumour cells into more sensitive phases of the cell cycle, and repair of sublethal damage), the use of hypofractionation in SABR has different radiobiological basis, which may include the ceramide pathway, the induction of antitumor immunity, and damage to the membranes, organelles, and vascular endothelium [12–21]. Potential mechanisms of the ablative effect of SABR [13–21] are higher biologically effective dose, modulation of the immunological response to the tumour, vascular and endothelial damage, cell and organelle membrane damage, ceramide pathway activation, eradication of dormant tumour stem cells.

The next sections in this review describe the potential benefits associated with the adoption of SABR in clinical conditions otherwise known to have dismal outcomes in terms of both local control and survival.

2.1. The Potential in Oligometasatic Disease

Recently, there has been a general acceptance in the subcategorization of metastatic disease into the categories of “oligometastases” and “multiple/disseminated metastases.” The term “oligo”-metastasis is applied for the condition having a presence of ≤5 metastases all within ≤3 sites. Given their limited volume, these are often considered “treatable” by the use of focal therapies such as surgery, radiofrequency ablation (RFA), and focussed RT [22, 23].

Surgical resection in general is invasive and may inflict morbidities and impact quality of life (QOL) adversely. Radiofrequency ablation (RFA) is less invasive in comparison to surgery but has its own set of limitations, most importantly in its inability to reach sites which are deep or closely related to critical structures. Further, the effectiveness of RFA can be diminished because of the heat-sink phenomenon which occurs due to the presence of blood vessels in the near proximity of the target tissue. The flowing blood within the vessels acts as a heat sink by carrying heat away from the site [24, 25]. The use of SABR for oligometastases promises to offer more durable local control and at times long term survival in comparison to conventional RT. This section describes the recent literature regarding the use of SABR for oligometastases involving the spinal column, brain, liver, lungs, adrenals, and lymph nodes.

The use of SABR for spinal (vertebral) metastases confers not just the ability to spare the spinal cord but also allows the delivery of higher doses which result in better duration of local control in comparison to conventional RT in naïve patients as well as among patients treated earlier with irradiation. The use of conventional RT for spinal metastases often achieves early palliation. However, it has been shown that most lesions treated with conventional RT progress at a median time of 3–6 months [26]. The use of SABR provides more prolonged local control in comparison to conventional RT. Yamada et al. have shown in a study involving 103 patients that the use of single fraction SABR (with doses of 18–24 Gy) provided a 90% local control rate, and a median time to local failure of 9 months. It was further noted that the dose of radiation delivered was a determinant of local response, while histology was not a determinant of local response [27]. Chang et al. in their study of 74 patients observed a 1-year progression free survival at 84% and observed no incidence of severe toxicity [28]. Gill et al. observed 1-year and 2-year local control to be 80% and 73%, respectively [29]. Amdur et al. observed a 95% local control rate, with most patients succumbing to progressive disease elsewhere [30]. Ryu et al. noted an overall pain control rate of 84% at 1 year [31]. The RTOG 0631 aims to establish the feasibility of image guided SABR. The study holds a phase-2/3 design, and the results of the phase-2 component have been published and they establish the feasibility and safety of image-guided SABR for patients with 1–3 vertebral metastases. The results of the phase-3 component of the study are yet to be published and aim to assess the effectiveness of SABR on pain relief and quality of life in comparison with conventional RT [32]. An outline of the recent evidences for the use of SABR in spinal metastases is provided in Table 1 [30–36].

The use of stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) for intracranial oligometastases has a long history of success in selected patient populations. Linskey et al. performed a systematic review of studies evaluating the benefit from adding an SRS boost after whole brain RT (WBRT) for brain metastases [37]. Level-I evidence was obtained, which proved that, among patients with a solitary brain metastases with a good performance status (KPS ≥ 70), the use of SRS after WBRT improved long-term survival in comparison to WBRT alone. There was better local control and improved functional status noted among patients with one to four metastases. Patil et al. presented the results of a Cochrane Database Systematic review analysing 358 patients which indicated significant improvements in functional status with the integration of SRS/SRT to WBRT. Additionally, significant overall survival benefits were observed among the subgroup of patients with single-metastases and belonging to the RTOG RPA-1 category [38]. An outline of the trials and meta-analysis conducted regarding the use of SRS/SRT for brain oligometastases is provided in Table 2 [37–43].

The treatment of hepatic oligometastases can often involve a curative approach utilizing surgical resection as a corner-stone [44, 45]. For patients who are inoperable, second-line options include the use of RFA, percutaneous acetic acid injection, percutaneous ethanol injection, LASER therapy, chemoembolization, and Yttrium-90 microspheres [46–49]. However, of late, SABR has been utilized in hepatic metastases and primaries with considerable success in terms of local control, consistently being above 70% at 1 year. Rusthoven et al. reported 100% two-year local control rates among patients with maximum lesion diameter <3 cm [50]. Lanciano et al. observed a dose-dependent increase in local control, with two-year local control rates being 75% and 38% for patients treated with a biologically equivalent dose (BED) of >100 Gy₁₀ and <100 Gy₁₀, respectively [51]. In 27 patients of unresectable liver metastases, Ambrosino et al. utilized image guided SABR and observed a 74.1% rate of local control and 25.9% patients had complete response. They noted a 33% incidence of mild to moderate hepatic toxicity [52]. Lee et al. in their phase-I trial involving 68 patients noted that despite delivering a dose which was assumed to hold a 20% risk of radiation induced liver disease, there was no incidence of grades 3–5 liver toxicity. In addition to the low toxicity, they observed a 1-year local control rate of 71% and a median survival of 17.6 months [53–55] (Table 3).

The use of SABR for oligometastases in the lungs has been one of the early applications for SABR. Very high 1-year local control rates have been reported with minimal risk of major toxicities. Okunieff et al. utilized SABR (ten fractions of 5 Gy each) to both oligo-and multiple metastases. With a very low risk of toxicity (2% risk of grade-3 toxicity), there was a very significant local control rate (94%) and an improved median survival in comparison to contemporary standards of care [56]. Rusthoven et al. used high dose SABR (three fractions of 20 Gy each) for patients with oligometastases to the lung and reported local control rates of 100% and 96% at 1 and 2 years, respectively [57]. Norihisa et al. in their retrospective study of 34 patients with oligometastatic lung disease treated with SABR noted a 2-year overall survival of 84.3% and local control rate of 90%. They utilized 12 Gy fractions of SABR to a total dose of 48 Gy in 18 patients and 60 Gy in 16 patients. It was notable that no patient who received 60 Gy had local progression [58]. The recent evidence for the use of SABR in pulmonary oligometastases is outlined in Table 4 [56–60].

It is not uncommon in clinical practise to encounter patients of various malignancies to relapse in isolated lymph nodes after prior treatment with various modalities. The use of SABR for isolated oligometastases in lymph nodes is a very attractive option, especially when surgery is not feasible. It must be mentioned here that there is no consensus upon the ideal dose and fractionation of SABR for lymph nodal oligometastases, but the same must be based upon factors such as the site of the target, size of the target, and the proximity to critical structures. Even though very little published literature exists on the use of SABR for lymph nodal oligometastases, the results with small series are very encouraging. Bae et al. treated 18 patients of abdominal lymph-nodal oligometastases. The 5-year local control rates were impressive at 57% [61]. Choi et al. reported a retrospective analysis which involves 30 patients of gynecological malignancies with isolated para-aortic nodal recurrences treated with SABR. The 4-year local control rate was 67.4%, and the median time to disease progression was 32 months [62]. Bignardi et al. studied 19 patients with retroperitoneal lymph nodal disease treated with SABR. The 2-year local control rate was about 78%. Though it was observed that most patients eventually show progressive disease at other sites, the local control can bestow significant duration of quality of life [63]. Jereczek-Fossa et al. treated 14 patients of prostate cancer with isolated lymph nodal metastases with SABR. While disease progression occurred at a mean time of 12.7 months, it was observed that no patients had in-field progression [64]. An outline of important trials evaluating the use of SABR for oligometastatic lymph nodal disease is provided in Table 5.

Of late, the use of SABR for adrenal metastases too has been attempted. The current studies have used a relatively low dose in comparison to SABR for other sites. Reasonable local control rates and no risk of severe toxicity have been reported (Table 6) [65, 66].

2.2. The Potential in Unresectable Malignancies

Surgery is the mainstay of care for malignancies such as the early-stage NSCLC (non-small cell lung cancer), HPB (hepatopancreaticobiliary), and RCC (renal cell carcinoma). However, surgery is not always feasible even among the T₁N₀ and T₂N₀ NSCLC, due to frequent comorbidities such as chronic obstructive pulmonary disease (COPD), cardiopulmonary insufficiencies, and, often, patient refusal [67, 68]. The use of standard fractionation RT to a dose of 60–66 Gy, even when combined with concurrent chemotherapy, has not offered durable responses [69].

SABR has been used in early stage NSCLC who were inoperable and has been shown to yield benefits comparable to surgery. It may be observed that SABR is not associated with a significant risk of immediate mortality unlike thoracic surgery. Also, the local control rates are excellent, consistently exceeding 95% at 1 year, and median overall-survival consistently exceeds 5 years. SABR is now being tested by a number of trials for operable lung cancers too. An outline of the recent trials addressing the use of SABR in early stage NSCLC is provided in Table 7 [70–75].

Hepatobiliary and pancreatic malignancies too require surgical resection as a part of radical management. However, various factors preclude operability, with less than 20–30% of these patients being operable at presentation. The use of contemporary management with chemotherapy and conventionally fractionated RT has only offered modest benefits in term of local control or survival [76, 77]. In hepatocellular carcinoma, SABR has been used in various settings and has demonstrated validity as a modality to prevent progression among patients awaiting definitive liver-transplantation, after nonresponse with chemoembolization and with a modified fractionation for patients with Child-Turcotte-Pugh Class B patients. An outline of these trials is provided in Table 8 [78–82]. The use of SABR in pancreatic cancer has been attempted with success either definitively in the case of inoperability, in combination with sequential gemcitabine chemotherapy, or as an adjuvant treatment after surgery with a close/positive margin (Table 9) [83–87].

Renal cell carcinoma (RCC) has traditionally been regarded as radioresistant. While RCC indeed is poorly responsive to conventionally fractionated RT, it is now being realized that hypofractionated RT delivering high doses per fraction could induce radiosensitivity. It is hypothesized that the delivery of higher doses per fraction activates the ceramide-pathway which in turn induces radiosensitivity in the otherwise radioresistant RCC. Further, the abscopal effect due to immunological mechanisms could add to the systemic disease control in combination with targeted drugs [88]. Wersäll et al. studied patients of metastatic and inoperable RCC treated with SABR. The observed local control rate was very high, at 90–98%. The benefit was higher for patients with three or less metastases [89]. Beitler et al. compiled a report describing the results with SABR for patients of RCC who refused definitive surgery. The nine patients were treated with 40 Gy in 5 fractions. At a median follow-up of 26.7 months, 4 of these 9 patients were alive. Since the 4 surviving patients have a follow-up duration of at least 4 years, the investigators concluded that hypofractionated radiotherapy could have a curative potential in organ confined RCC who could be inoperable for any reason [90]. Svedman et al. studied 7 patients of RCC within a single functioning kidney treated with 30 Gy in 3 fractions. Only one patient failed locally after a follow-up duration of 54 months [91]. Siva et al. have published a systematic review of the use of SABR for primary RCC with regards to local control and toxicity. They included three-prospective and seven-retrospective studies in the analysis. They derived a local control rate of about 93.9%, and a severe toxicity (grade-3 or higher) rate of 3.8%. They did conclude that while there was promising rates of local control, there was a need for accumulating more evidence for reaching at a consensus regarding the ideal dose-fractionation for treatment of primary RCC in medically inoperable patients [92] (Table 10).

2.3. The Potential in Reirradiation

The outcome of patients with local recurrence of malignancy within an area already treated with full dose of radiation is often dismal. The reuse of RT is often limited by the previous dose and the duration between previous irradiation and relapse. It is seldom possible to use a full tumoricidal dose with conventional techniques to achieve local control [93, 94]. Recently, there has been considerable interest in the use of SABR for reirradiation in patients with prior history of radiotherapy (Table 11).

In head and neck malignancies, where RT is a prime treatment modality, a dose with curative intent is most often delivered to the primary and nodal areas. In cases of recurrence, as in nasopharyngeal cancers, the use of surgery for salvage is often fraught with anatomical limitations and serious risk of morbidities. Ozyigit et al. compared the outcomes of SABR versus the use of 3DCRT (three-dimensional conformal radiotherapy) with or without brachytherapy for reirradiation after local relapse in patients with nasopharyngeal carcinoma [95]. The observed response rates with the two approaches were similar, however, with much lower rates of toxicities among patients treated with SABR. Iwata et al. reported on the feasibility of SABR for salvage of post-RT recurrence in sinonasal malignancies [96]. In general, SABR may have an important role in the reirradiation of head and neck malignancies given the high conformality and the ability to spare critical structures such as the brain and the spinal cord. Additionally, the lower overall treatment times associated with SABR may add further benefits from the QOL point of view.

The preferred treatment for an in-field recurrence after previous full dose radiotherapy for abdominal and pelvic malignancies would call for surgical resection. However, surgery is not often feasible given the associated morbidities expectable with resections, with disease often situated to critical structures such as the iliac blood vessels. Again, SABR for reirradiation has a potential for eradication/long term control of postradiation in-field recurrences in abdominal and pelvic malignancies [64, 95–97].

Spinal column metastases are very frequently treated with conventional radiotherapy for palliation of pain and spinal cord compression, many times in conjunction with decompressive stabilizing surgery. Commonly used doses for conventional radiotherapy in the palliation of spinal metastases include 8 Gy in a single fraction to 40 Gy in 20 fractions and various intermediate schedules. Though conventional RT provides good pain relief, the duration of pain control is generally low, in the range of 3–6 months. On eventual resurgence of pain, the use of further conventional RT is generally avoided in view of the risk of spinal cord toxicity. The ability of image-guided and intensity modulated SABR to spare the spinal cord has recently gained considerable interest. Sahgal et al. in their series used SABR both in patients with no prior radiation (23 patients) and in those with history of prior conventional irradiation (37 patients). With the use of a median dose of 24 Gy in 3 fractions, the overall 2-year progression free probability was as high as 85%. Importantly, it was observed that there was no significant difference in overall survival or progression free probability among patients being treated with SABR irrespective of whether they had been previously irradiated [98]. Choi et al. in their retrospective series of 42 patients reirradiated with SABR after prior RT noted a 1-year local control rate of 73%. It was however noted that patients with a time to retreatment (time interval between prior radiotherapy and SABR) of <12 months was a significant predictor of local failure, with these patients having a 1-year local control rate of 58%. One patient of these 42 patients developed grade-4 neurotoxicity [99]. Sterzing et al. utilized SABR to treat 36 patients with prior history of RT. They recorded a 2-year local control of 63%, and no incidence of severe toxicity was observed [100]. Similar studies by Garg et al. and Chang et al. observed 1-year local control rates of 76% and 81% [101, 102]. Mahadevan et al. observed a median progression free survival of 9 months and that 65% of patients had pain relief on reirradiation with SABR [103].

Most patients diagnosed with unresectable NSCLC get treated with concurrent chemoradiotherapy. However, despite a degree of local control, up to 85% of patients subsequently suffer locoregional failures [104, 105]. The proportion of patients undergoing reirradiation with conventional RT is very low because of concerns such as spinal cord, esophagus, pulmonary, and cardiac toxicities. Recently, SABR has been utilized for reirradiation with an intention to prolong local control while minimising radiation exposure to the spinal cord and esophagus. It must however be emphasized here that the ideal dose-fractionation schemes are unknown and may need to be tailored to the individual patient with regards to prior dose of radiation, duration between prior irradiation, proximity to other critical structures, and overall condition of the patient. Poltinnikov et al. described 17 patients of NSCLC being reirradiated with SABR. All patients had been treated previously to a dose of at least 50 Gy. Though the median overall survival was just 5.5 months, it was remarkable that 11 of 13 patients who were symptomatic with shortness of breath had improved with SABR [106]. Studies by Kelly et al. and Coon et al. both observed 1-year local control rates of 92%. The observed 1-year survival rates were 82% and 67%, respectively [107, 108].

3. Conclusions

Despite the large volume of published evidence testifying the potential benefits with the use of SABR, its clinical adoption, particularly in developing countries remains low. It is attributable to various factors, ranging from a lack of awareness among clinicians, to a more serious therapeutic nihilism. While cost is often cited as a factor against SABR, it must be noted that the costs associated with a short course of SABR often is comparable in the overall costs of a protracted course of conventional RT which may easily extend to weeks in duration.

There is an urgent need for an initiative not just from oncologists, but also from the institutional administrations and industry as well as the governments. The investment involved in the procurement of a machine capable of SABR may be high, but from the tax-payer’s point of view, it would be “money spent well.” After all, we are fighting a “war on cancer.” Countries across the world—those involved in actual military battles and those not involved in conflict—spend a large amount of funds upon expensive military hardware. Governments all around the world which speak about “war on cancer,” in a hypocritical way neglect genuine spending directed towards the “war on cancer.”

The cost of military war hardware is far more expensive in comparison to the hardware and software required for the “war on cancer.” For an example, the average cost of a modern fighter-jet is US$100–200 million per unit [109, 110]. With the money required to buy a single modern fighter-jet, more than a dozen linear-accelerators capable of performing SABR can be installed.

Unless genuine action is taken by governments across the world to spend adequately upon making newer radiotherapy technologies to the masses, the “war on cancer” could be regarded as a “farce.” May SABR be perceived as a basic necessity in our war on cancer, rather than being regarded as a luxury for some.

Key Messages

While conventionally fractionated radiotherapy and surgery in the treatment of oligometastatic disease may indeed achieve a degree of palliation, the local responses are often short-lived. Stereotactic ablative radiotherapy (SABR) offers local responses which have been durable, hence achieving long-term palliation in most, and cure in many.

Conflict of Interests

All authors declare that there is no conflict of interests.

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Copyright © 2014 Sridhar P. Susheela et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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