Suppression of Adenosine Deaminase and Xanthine Oxidase Activities by Mineralocorticoid and Glucocorticoid Receptor Blockades Restores Renal Antioxidative Barrier in Oral Contraceptive-Treated Dam

Figure 1

Effect of glucocorticoid (GR) and mineralocorticoid (MR) receptor blockade on kidney weight in Wistar dams exposed to postpartum combined oral contraceptives (COC). Postpartum COC treatment, GR, and MR blockade did not affect kidney weight. Post gestational COC exposure, GR and MR blockade were carried out for eight weeks after the 3-week postgestational period. Data were presented as , and was taken as statistically significant. vs. DAM; ^# vs. DAM+COC. Data were analyzed by one-way ANOVA and Bonferroni’s post hoc analysis. DAM: control; DAM+COC: combined oral contraceptive exposure; DAM+COC+GR: COC exposure with glucocorticoid receptor blockade; DAM+COC+MR: COC exposure with mineralocorticoid receptor blockade.