Suppression of Adenosine Deaminase and Xanthine Oxidase Activities by Mineralocorticoid and Glucocorticoid Receptor Blockades Restores Renal Antioxidative Barrier in Oral Contraceptive-Treated Dam

Figure 3

Effect of glucocorticoid (GR) and mineralocorticoid (MR) receptor blockades on glutathione-dependent antioxidant system in Wistar dams exposed to combined oral contraceptives (COC). GR and MR blockades increased renal G6PD (glucose-6-phosphate dehydrogenase) (a), increased NADPH (reduced nicotinamide adenine dinucleotide phosphate) (b), increased GPx (glutathione peroxidase) (c), and increased GSH/GSSG (reduced glutathione/oxidized glutathione) ratio (d) in COC-treated Wistar rat dams. Post gestational COC exposure, GR and MR blockades were carried out for eight weeks after the 3-week postgestational period. Data were presented as , and was taken as statistically significant. vs. DAM; ^# vs. DAM+COC. Data were analyzed by one-way ANOVA and Bonferroni’s post hoc analysis. DAM: control; DAM+COC: combined oral contraceptive exposure; DAM+COC+GR: COC exposure with glucocorticoid receptor blockade; DAM+COC+MR: COC exposure with mineralocorticoid receptor blockade.

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