Table of Contents
Journal of Respiratory Medicine
Volume 2013, Article ID 756483, 6 pages
Research Article

Diagnostic Utility of Transbronchial Needle Aspiration in Malignant Endobronchial Lesions: Relevance to Lesions’ Characteristics

1Department of Chest Diseases, Faculty of Medicine, Assiut University, Assiut 71516, Egypt
2Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut 71516, Egypt
3Department of Pathology, Faculty of Medicine, Assiut University, Assiut 71516, Egypt

Received 27 June 2013; Revised 9 August 2013; Accepted 22 August 2013

Academic Editor: Akira Mogi

Copyright © 2013 Sherif A. A. Mohamed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this prospective study, we aimed to report our experience with the diagnostic utility of transbronchial needle aspiration (TBNA) in patients with malignant endobronchial lesions detected during routine bronchoscopy. Ninety-four patients were enrolled. TBNA and conventional diagnostic techniques (CDTs: forceps biopsy, brushing, and washing) were performed in all patients. Endobronchial lesions were classified into exophytic mass lesions (EMLs), submucosal disease (SD), and peribronchial disease (PD). The diagnostic yields of TBNA and CDT alone and together were compared according to the lesions’ types, histopathology, and locations. During 3-year period, the addition of TBNA to CDT improved bronchoscopic sensitivity from 70.2% to 94.7% in all lesion types. Addition of TBNA to CDT increased the diagnostic success from 74% to 95% and from 50% to 94% in NSCLC and SCLC, respectively. The diagnostic success was increased in all localizations by the addition of TBNA to CDT, particularly for lesions located at the trachea, main bronchi, and upper lobes. We conclude that the addition of TBNA to CDT increases the diagnostic yield in patients with visible malignant endobronchial lesions, particularly in peribronchial disease, and improves the diagnostic yield of bronchoscopy, in both NSCLC and SCLC and in all bronchoscopic locations, particularly in central and upper lobar lesions.