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Journal of Sensors
Volume 2010, Article ID 452163, 7 pages
Research Article

Real-Time Noninvasive Measurement of Glucose Concentration Using a Microwave Biosensor

1Department of Physics and Basic Science Institute for Cell Damage Control, Sogang University, Seoul 121-742, Republic of Korea
2Department of Physics, Sam Houston State University, Huntsville, TX 77341, USA

Received 27 February 2010; Accepted 13 December 2010

Academic Editor: Hai Xiao

Copyright © 2010 Arsen Bababjanyan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We measured the glucose concentration by using the real-time electromagnetic interaction between probe-tip and glucose solution using a microwave biosensor. The microwave biosensor, consisting of a dielectric resonator coupled to the probe-tip, allows observation of the small variation of the glucose concentration changes in the ranges of 0–300 mg/ml by measuring the microwave reflection coefficient . We could observe the concentration of glucose with a detectable resolution up to 1 mg/ml at an operating frequency of about  GHz. The change of the glucose concentration is directly related to the change of the reflection coefficient due to the electromagnetic interaction between the microwave resonator and the glucose solution. The operational principal is explained by the plane-wave solution model. The measured signal-to-noise ratio was about 37 dB, and the minimum detectible signal was about 0.003 dB/(mg/ml). A glucose biosensor using a microwave resonator with probe provides a unique approach for glucose real-time monitoring.