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Journal of Sensors
Volume 2011, Article ID 735279, 6 pages
http://dx.doi.org/10.1155/2011/735279
Research Article

Electrochemical Capacitance DNA Sensing at Hairpin-Modified Au Electrodes

Department of Chemistry and Center for Advanced Nanoscale Materials, University of Puerto Rico, Río Piedras Campus, P.O. Box 23346, San Juan, PR 00931-3346, USA

Received 1 September 2010; Revised 7 April 2011; Accepted 23 June 2011

Academic Editor: Jiri Homola

Copyright © 2011 Joel Rivera-Gandía et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. M. Herne and M. J. Tarlov, “Characterization of DNA probes immobilized on gold surfaces,” Journal of the American Chemical Society, vol. 119, no. 38, pp. 8916–8920, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. S. O. Kelley, J. K. Barton, N. M. Jackson et al., “Orienting DNA helices on gold using applied electric fields,” Langmuir, vol. 14, no. 24, pp. 6781–6784, 1998. View at Publisher · View at Google Scholar · View at Scopus
  3. C. S. Lee, S. E. Baker, M. S. Marcus, W. Yang, M. A. Eriksson, and R. J. Hamers, “Electrically addressable biomolecular functionalization of carbon nanotube and carbon nanofiber electrodes,” Nano Letters, vol. 4, no. 9, pp. 1713–1716, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. W. Yang, O. Auciello, J. E. Butler et al., “DNA-modified nanocrystalline diamond thin-films as stable, biologically active substrates,” Nature Materials, vol. 1, no. 4, pp. 253–257, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Knickerbocker, T. Strother, M. P. Schwartz et al., “DNA-modified diamond surfaces,” Langmuir, vol. 19, no. 6, pp. 1938–1942, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Yang, J. E. Butler, J. N. Russell Jr., and R. J. Hamers, “Interfacial electrical properties of DNA-modified diamond thin films: intrinsic response and hybridization-induced field effects,” Langmuir, vol. 20, no. 16, pp. 6778–6787, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. S. P. A. Fodor, “Massively parallel genomics,” Science, vol. 277, no. 5324, pp. 393–395, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. S. P. A. Fodor, J. L. Read, M. C. Pirrung, L. Stryer, A. T. Lu, and D. Solas, “Light-directed, spatially addressable parallel chemical synthesis,” Science, vol. 251, no. 4995, pp. 767–773, 1991. View at Google Scholar · View at Scopus
  9. D. J. Lockhart and E. A. Winzeler, “Genomics, gene expression and DNA arrays,” Nature, vol. 405, no. 6788, pp. 827–836, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. M. L. Bulyk, E. Gentalen, D. J. Lockhart, and G. M. Church, “Quantifying DNA-protein interactions by double-stranded DNA arrays,” Nature Biotechnology, vol. 17, no. 6, pp. 573–577, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Chee, R. Yang, E. Hubbell et al., “Accessing genetic information with high-density DNA arrays,” Science, vol. 274, no. 5287, pp. 610–614, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. M. B. Esch, L. E. Locascio, M. J. Tarlov, and R. A. Durst, “Detection of viable Cryptosporidium parvum using DNA-modified liposomes in a microfluidic chip,” Analytical Chemistry, vol. 73, no. 13, pp. 2952–2958, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. A. B. Steel, T. M. Herne, and M. J. Tarlov, “Electrochemical quantitation of DNA immobilized on gold,” Analytical Chemistry, vol. 70, no. 22, pp. 4670–4677, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. A. B. Steel, T. M. Herne, and M. J. Tarlov, “Electrostatic interactions of redox cations with surface-immobilized and solution DNA,” Bioconjugate Chemistry, vol. 10, no. 3, pp. 419–423, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. L. He, M. D. Musick, S. R. Nicewarner et al., “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” Journal of the American Chemical Society, vol. 122, no. 38, pp. 9071–9077, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. J. M. Brockman, A. G. Frutos, and R. M. Corn, “A multistep chemical modification procedure to create dna arrays on gold surfaces for the study of protein-DNA interactions with surface plasmon resonance imaging,” Journal of the American Chemical Society, vol. 121, no. 35, pp. 8044–8051, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. M. L. Sauthier, R. Lloyd Carroll, C. B. Gorman, and S. Franzen, “Nanoparticle layers assembled through DNA hybridization: characterization and optimization,” Langmuir, vol. 18, no. 5, pp. 1825–1830, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Cao, R. Jin, and C. A. Mirkin, “DNA-modified core-shell Ag/Au nanoparticles,” Journal of the American Chemical Society, vol. 123, no. 32, pp. 7961–7962, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. L. M. Demers, C. A. Mirkin, R. C. Mucic et al., “A fluorescence-based method for determining the surface coverage and hybridization efficiency of thiol-capped oligonucleotides bound to gold thin films and nanoparticles,” Analytical Chemistry, vol. 72, no. 22, pp. 5535–5541, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. S. H. Brewer, S. J. Anthireya, S. E. Lappi, D. L. Drapcho, and S. Franzen, “Detection of DNA hybridization on gold surfaces by polarization modulation infrared reflection absorption spectroscopy,” Langmuir, vol. 18, no. 11, pp. 4460–4464, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Fan, K. W. Plaxco, and A. J. Heeger, “Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 16, pp. 9134–9137, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Tyagi and F. R. Kramer, “Molecular beacons: probes that fluoresce upon hybridization,” Nature Biotechnology, vol. 14, no. 3, pp. 303–308, 1996. View at Google Scholar · View at Scopus
  23. S. Tyagi, D. P. Bratu, and F. R. Kramer, “Multicolor molecular beacons for allele discrimination,” Nature Biotechnology, vol. 16, no. 1, pp. 49–53, 1998. View at Publisher · View at Google Scholar · View at Scopus
  24. L. G. Kostrikis, S. Tyagi, M. M. Mhlanga, D. D. Ho, and F. R. Kramer, “Spectral genotyping of human alleles,” Science, vol. 279, no. 5354, pp. 1228–1229, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. S. A. E. Marras, F. Russell Kramer, and S. Tyagi, “Multiplex detection of single-nucleotide variations using molecular beacons,” Genetic Analysis—Biomolecular Engineering, vol. 14, no. 5-6, pp. 151–156, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Bonnet, S. Tyagi, A. Libchaber, and F. R. Kramer, “Thermodynamic basis of the enhanced specificity of structured DNA probes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 11, pp. 6171–6176, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Bar-Ziv and A. Libchaber, “Effects of DNA sequence and structure on binding of RecA to single-stranded DNA,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 16, pp. 9068–9073, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Gao, L. K. Wolf, and R. M. Georgiadis, “Secondary structure effects on DNA hybridization kinetics: a solution versus surface comparison,” Nucleic Acids Research, vol. 34, no. 11, pp. 3370–3377, 2006. View at Google Scholar · View at Scopus
  29. G. Liu, Y. Wan, V. Gau et al., “An enzyme-based E-DNA sensor for sequence-specific detection of femtomolar DNA targets,” Journal of the American Chemical Society, vol. 130, no. 21, pp. 6820–6825, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Song, Z. Liang, J. Zhang, L. Wang, G. Li, and C. Fan, “Gold-nanoparticle-based multicolor nanobeacons for sequence-specific DNA analysis,” Angewandte Chemie—International Edition, vol. 48, no. 46, pp. 8670–8674, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Rivera-Gandía and C. R. Cabrera, “Self-assembled monolayers of 6-mercapto-1-hexanol and mercapto-n-hexyl-poly(dT)18-fluorescein on polycrystalline gold surfaces: an electrochemical impedance spectroscopy study,” Journal of Electroanalytical Chemistry, vol. 605, no. 2, pp. 145–150, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. W. Cai, J. R. Peck, D. W. van der Weide, and R. J. Hamers, “Direct electrical detection of hybridization at DNA-modified silicon surfaces,” Biosensors and Bioelectronics, vol. 19, no. 9, pp. 1013–1019, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. B. C. Jacquot, N. Muñoz, D. W. Branch, and E. C. Kan, “Non-Faradaic electrochemical detection of protein interactions by integrated neuromorphic CMOS sensors,” Biosensors and Bioelectronics, vol. 23, no. 10, pp. 1503–1511, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. E. Katz and I. Willner, “Probing biomolecular interactions at conductive and semiconductive surfaces by impedance spectroscopy: routes to impedimetric immunosensors, DNA-sensors, and enzyme biosensors,” Electroanalysis, vol. 15, no. 11, pp. 913–947, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Sharon, R. Freeman, T. V. Ran, and I. Willner, “Impedimetric or ion-sensitive field-effect transistor (ISFET) aptasensors based on the self-assembly of au nanoparticle-functionalized supramolecular aptamer nanostructures,” Electroanalysis, vol. 21, no. 11, pp. 1291–1296, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Wang, “Towards genoelectronics: electrochemical biosensing of DNA hybridization,” Chemistry-A European Journal, vol. 5, p. 1681, 1999. View at Google Scholar
  37. S. R. Mikklessen, “Electrochecmical biosensors for DNA sequence detection,” Electroanalysis, vol. 8, p. 15, 1996. View at Google Scholar
  38. E. Paleček and M. Fojta, “Detecting DNA hybridization and damage,” Analytical Chemistry, vol. 73, no. 3, 2001. View at Google Scholar · View at Scopus
  39. H. Aoki, P. Buhlmann, and Y. Umezawa, “Electrochemical detection of a one-base mismatch in an oligonucleotide using ion-channel sensors with self-assembled PNA monolayers,” Electroanalysis, vol. 12, no. 16, pp. 1272–1276, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. A. J. Bard and L. R. Faulkner, Electrochemical Methods: Fundamentals and Applications, chapter 10, 2nd edition, 2001.
  41. C. Xi, M. Balberg, S. A. Boppart, and L. Raskin, “Use of DNA and peptide nucleic acid molecular beacons for detection and quantification of rRNA in solution and in whole cells,” Applied and Environmental Microbiology, vol. 69, no. 9, pp. 5673–5678, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. X. Liu and W. Tan, “A fiber-optic evanescent wave DNA biosensor based on novel molecular beacons,” Analytical Chemistry, vol. 71, p. 5054, 1999. View at Google Scholar