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Journal of Sensors
Volume 2018, Article ID 3019259, 8 pages
https://doi.org/10.1155/2018/3019259
Research Article

Detection of Immunoglobulin E with a Graphene-Based Field-Effect Transistor Aptasensor

1Department of Electrical and Computer Engineering, University of Illinois, Chicago, IL 60607, USA
2Department of Bioengineering, University of Illinois, Chicago, IL 60607, USA
3Department of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697, USA
4Department of Electrical Engineering and Computer Science, University of California, Irvine, CA 92697, USA
5Department of Physics, University of Illinois, Chicago, IL 60607, USA

Correspondence should be addressed to Sidra Farid; moc.liamg@dirafardis

Received 5 February 2018; Accepted 28 June 2018; Published 22 July 2018

Academic Editor: Heinz C. Neitzert

Copyright © 2018 Yi Lan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

DNA aptamers have the ability to bind to target molecules with high selectivity and therefore have a wide range of clinical applications. Herein, a graphene substrate functionalized with a DNA aptamer is used to sense immunoglobulin E. The graphene serves as the conductive substrate in this field-effect-transistor-like (FET-like) structure. A voltage probe in an electrolyte is used to sense the presence of IgE as a result of the changes in the charge distribution that occur when an IgE molecule binds to the IgE DNA-based aptamer. Because IgE is an antibody associated with allergic reactions and immune deficiency-related diseases, its detection is of utmost importance for biomedical applications.