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Journal of Skin Cancer
Volume 2011, Article ID 370605, 4 pages
Case Report

A Troubling Diagnosis of Verrucous Squamous Cell Carcinoma (“the Bad Kind” of Keratosis) and the Need of Clinical and Pathological Correlations: A Review of the Literature with a Case Report

1Section of Anatomic Pathology and Cytopathology, Department of Surgical Sciences, University of Foggia, Viale L Pinto 1, 71100 Foggia, Italy
2Department of Odontostomatological, Orthodontical and Surgical Sciences, Second University of Naples, Via De Crecchio 1, 80138 Naples, Italy
3Section of Oral Pathology, University of Foggia, Viale L Pinto 1, 71100 Foggia, Italy
4Division of Head and Neck Surgery and Oncology, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

Received 27 July 2010; Accepted 28 September 2010

Academic Editor: Silvia Moretti

Copyright © 2011 A. Santoro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Verrucous carcinoma (also known as Ackerman tumor) is an uncommon exophytic low-grade well-differentiated variant of squamous cell carcinoma. This neoplasm typically involves the oral cavity, larynx, genitalia, skin, and esophagus. It is well known for its locally aggressiveness and for its clinically slow-growing behaviour with minimal metastatic potential. Verrucous carcinoma of oral cavity is so closely aligned with the use of snuff and chewing tobacco that it has been called the “snuff dipper's cancer”. Recent studies have proved the role of HPV. The typical clinical presentation of oral verrucous carcinoma has long been known, as its remarkably innocuous appearance and biological behaviour. In this work, we report a review of the scientific literature and describe a troublesome case of oral verrucous cancer.