Figure 2: Methods for initiating, suspending, or altering melanocyte regeneration from MSCs. Top: representative wild-type zebrafish pigment pattern. Left: representative examples of fish treated with IWR-1 and NCP; caudal fin regeneration is delayed with IWR-1, melanocytes ablated with NCP (lateral stripe is shown after treatment). Right: representative examples of fish exposed to UVA or UVB radiation. UVA irradiation following NCP treatment impairs MSCs function, altering pigment pattern; UVB irradiation before fin amputation impairs MSCs function, altering pigment pattern or disrupts epimorphic regeneration of caudal fin.