Figure 1: Germ cell proteins are often expressed in melanoma. Shown is a melanoma line DM2N stained with (a) and without (b) a primary antibody to REC8 (ProteinTech, Chicago, IL), a protein involved in chromosomal cohesion and crossover events in meiosis. The red staining (a) reveals that REC8 is abundantly expressed and is heterogeneous both in the level of expression and localization. It is possible that REC8 and other expressed germ cell proteins contribute to the chromosomal instability seen in melanoma and others tumors (size bar 50 μm).